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Titolo:
EPIDERMAL GROWTH-FACTOR INDUCES CELL-PROLIFERATION IN MOUSE PANCREAS AND SALIVARY-GLANDS
Autore:
OHLSSON B; JANSEN C; IHSE I; AXELSON J;
Indirizzi:
UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT SURG S-22185 LUND SWEDEN
Titolo Testata:
Pancreas
fascicolo: 1, volume: 14, anno: 1997,
pagine: 94 - 98
SICI:
0885-3177(1997)14:1<94:EGICIM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-ALPHA; FACTOR EGF; STIMULATION; MICE; OVEREXPRESSION; RECEPTOR; INSULIN; BINDING; CANCER; LIVER;
Keywords:
EPIDERMAL GROWTH FACTOR; CELL PROLIFERATION; PANCREAS; PAROTID GLAND; SUBMANDIBULAR GLAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
B. Ohlsson et al., "EPIDERMAL GROWTH-FACTOR INDUCES CELL-PROLIFERATION IN MOUSE PANCREAS AND SALIVARY-GLANDS", Pancreas, 14(1), 1997, pp. 94-98

Abstract

Epidermal growth factor (EGF) is a mitogenic stimulus in many tissuesand occurs in large amounts in the pancreas and salivary glands. Whether EGF is mitogenic in the pancreas is controversial, and the EGF effect has not been studied in the salivary glands. Therefore, the aim ofthe present study was to investigate the possible effects on the pancreas and parotid and submandibular glands at different time intervals after exogenous EGF administration Human recombinant EGF was infused subcutaneously by osmotic minipumps in three groups of mice (for 1, 3, and 7 days, respectively) at a dosoge of 10 mu g/kg/h (1.6 mu mol/kg/h). Tritiated thymidine was infused intraperitoneally by osmotic minipumps for the same time periods. but only for the last 3 days in the 7-day group. After 1 day the pancreas increased in weight and the increase persisted throughout the study. No effect was seen on the parotid orsubmandibular gland wet weight. A slight transient increase in pancreas protein content was observed, whereas amylase content was unaffected. The labeling index of serous and ductal cells in the parotid gland increased from the third day. After 7 days, all cell types studied in the pancreas and parotid and submandibular glands were in a hyperproliferative state. The results show that EGF evoked a strong proliferative response on all cell types studied in the pancreas and parotid and submandibular glands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:58:18