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Titolo:
ADULT GRANULOSA-CELL TUMOR OF THE OVARY - A RETROSPECTIVE STUDY OF 45CASES
Autore:
PAUTIER P; LHOMME C; CULINE S; DUVILLARD P; MICHEL G; BIDART JM; GERBAULET A; DROZ JP;
Indirizzi:
INST GUSTAVE ROUSSY,SERV GYNECOL DOCTEUR C LHOMME,RUE CAMILLE DESMOULINS F-94805 VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT MED ONCOL VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT PATHOL VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT SURG ONCOL VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT BIOL CLIN F-94805 VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT RADIOTHERAPY F-94805 VILLEJUIF FRANCE
Titolo Testata:
International journal of gynecological cancer
fascicolo: 1, volume: 7, anno: 1997,
pagine: 58 - 65
SICI:
1048-891X(1997)7:1<58:AGTOTO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLEOMYCIN COMBINATION CHEMOTHERAPY; CIS-PLATINUM; INHIBIN; MARKER; VINBLASTINE; ESTRADIOL;
Keywords:
ESTRADIOL; GRANULOSA CELL TUMOR; INHIBIN; OVARIAN TUMOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P. Pautier et al., "ADULT GRANULOSA-CELL TUMOR OF THE OVARY - A RETROSPECTIVE STUDY OF 45CASES", International journal of gynecological cancer, 7(1), 1997, pp. 58-65

Abstract

This study describes 45 cases of adult granulosa-cell tumors seen in our institution between 1976 and 1993. The median age was 46.5 years (12-77) and 18 women were postmenopausal. Vaginal bleeding was present in one-third of cases; other complaints were abdominal pain (28%) and the presence of a pelvic mass (47%). The tumor size was variable (<3 cm to 30 cm, median 11.5 cm). FIGO stages were: stage I: 30 (73%) (19 Ia, seven Ic, four I unknown); stage II: seven (17%) (two IIa, five IIC); stage III: three (7%) (one IIIb, two IIIc). Two adenocarcinomas and13 cases of hyperplasia were found in 25 endometrial samples available. The initial therapy for all the cases was surgery, consisting in 34patients of hysterectomy, bilateral salpingo-oophorectomy, +/- tumor resection. Sixteen patients received adjuvant therapy as well: chemotherapy (CT) alone for 12, radiotherapy (RT) alone for two, and CT + RT for two patients. Among the 39 patients who achieved a complete response after initial therapy, 15 patients have relapsed (pelvic recurrences) (38.5%) including six stage Ia (three received only conservative surgery). All the recurrent tumors were resected and 14/15 had CT (13/14with cisplatin). The overall survival rate was 77.2% at 5 years, 66.5% at 10 years, and 41.2% at 20 years. A statistically significant difference was found between the survival of patients with stage Ia disease (75% at 10 and 15 years) and that of other patients (60% at 10 years, and <50% at 15 years). Serum estradiol and serum inhibin were measured in some patients and the results are described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:26:36