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Titolo:
STUDY OF CHOROIDAL BLOOD-FLOW BY COMPARISON OF SLO FLUORESCEIN ANGIOGRAPHY AND MICROSPHERES
Autore:
DUIJM HF; RULO AHF; ASTIN M; MAEPEA O; VANDENBERG TJTP; GREVE EL;
Indirizzi:
UNIV AMSTERDAM,GLAUCOMA CTR,DEPT OPHTHALMOL NL-1012 WX AMSTERDAM NETHERLANDS UNIV AMSTERDAM,DEPT MED PHYS NL-1012 WX AMSTERDAM NETHERLANDS NETHERLANDS OPHTHALM RES INST NL-1100 AC AMSTERDAM NETHERLANDS PHARMACIA UPPSALA AB,PROSTAGLANDIN RES UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT OPHTHALMOL UPPSALA SWEDEN
Titolo Testata:
Experimental Eye Research
fascicolo: 6, volume: 63, anno: 1996,
pagine: 693 - 704
SICI:
0014-4835(1996)63:6<693:SOCBBC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCANNING LASER OPHTHALMOSCOPY; HIGH INTRAOCULAR-PRESSURE; OPTIC-NERVE HEAD; RETINAL MICROCIRCULATION; OCULAR PRESSURE; CIRCULATION; GLAUCOMA; BRAIN; CAT; AUTOREGULATION;
Keywords:
OCULAR BLOOD FLOW; MICROSPHERES; FLUORESCEIN ANGIOGRAPHY; COMPUTER-ASSISTED IMAGE ANALYSIS; CHOROID; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
H.F. Duijm et al., "STUDY OF CHOROIDAL BLOOD-FLOW BY COMPARISON OF SLO FLUORESCEIN ANGIOGRAPHY AND MICROSPHERES", Experimental Eye Research, 63(6), 1996, pp. 693-704

Abstract

Choroidal hemodynamics estimated with parameters describing the dye build-up curves obtained with video fluorescein angiography, were compared with a classical regional blood flow measurement: radioactively labelled microspheres. Video fluorescein angiograms (Rodenstock's SLO 101) and microspheres blood flow measurements were made in 13 anaesthetized pigmented rabbits. Ocular perfusion pressures were varied from 60 to 15 mmHg by changing the intraocular pressure. The angiographically derived dye build-up curves were described by means of an exponential model. One of the model parameters is the time constant tau theoretically reflecting local blood refreshment time. Labelled microspheres actas a non-recirculating blood now indicator, enabling the estimation of regional blood flows. The relation between choroidal blood flow and perfusion pressure is nearly linear, suggesting the passive nature of choroidal vasculature. There is a significant correlation between tau and microspheres flow (R = 0.67, P < 0.01). According to the rheological model the product of blood now and tau corresponds to the relevant blood volume. Hence, a function for the volume of the choriocapillarisas a function of perfusion pressure was established. The model parameter tau can be interpreted as the local blood refreshment time. Since the parameter tau, unlike microspheres, can be used clinically, tau may be used to retrieve information on choroidal hemodynamics in clinical practice. Information on the spatial distribution of choroidal hemodynamics is also obtained. (C) 1996 Academic Press Limited

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Documento generato il 30/11/20 alle ore 16:42:20