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Titolo:
NYVAC-PF7 - A POXVIRUS-VECTORED, MULTIANTIGEN, MULTISTAGE VACCINE CANDIDATE FOR PLASMODIUM-FALCIPARUM MALARIA
Autore:
TINE JA; LANAR DE; SMITH DM; WELLDE BT; SCHULTHEISS P; WARE LA; KAUFFMAN EB; WIRTZ RA; DETAISNE C; HUI GSH; CHANG SP; CHURCH P; HOLLINGDALE MR; KASLOW DC; HOFFMAN S; GUITO KP; BALLOU WR; SADOFF JC; PAOLETTI E;
Indirizzi:
VIROGENET CORP,465 JORDAN RD RENSSELAER TECHNOL PK TROY NY 12180 VIROGENET CORP TROY NY 12180 WALTER REED ARMY INST RES WASHINGTON DC 20307 PASTEUR MERIEUX SERUMS & VACCINS F-69280 MARCY LETOILE FRANCE UNIV HAWAII,JOHN A BURNS SCH MED,DEPT TROP MED & MED MICROBIOL HONOLULU HI 96816 USN,MED RES INST,MALARIA PROGRAM BETHESDA MD 20889 UNIV LEEDS,DEPT BIOL LEEDS LS2 9JT W YORKSHIRE ENGLAND NIAID,MALARIA RES LAB BETHESDA MD 20892 CONNAUGHT LABS INC SWIFTWATER PA 18370
Titolo Testata:
Infection and immunity
fascicolo: 9, volume: 64, anno: 1996,
pagine: 3833 - 3844
SICI:
0019-9567(1996)64:9<3833:N-APMM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETICALLY ENGINEERED POXVIRUSES; SPOROZOITE SURFACE PROTEIN-2; RECOMBINANT SERA PROTEIN; LETHAL JEV INFECTION; VIRUS GLYCOPROTEIN-D; ASEXUAL BLOOD STAGES; CIRCUMSPOROZOITE PROTEIN; PROTECTIVE IMMUNITY; AOTUS MONKEYS; ESCHERICHIA-COLI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Tine et al., "NYVAC-PF7 - A POXVIRUS-VECTORED, MULTIANTIGEN, MULTISTAGE VACCINE CANDIDATE FOR PLASMODIUM-FALCIPARUM MALARIA", Infection and immunity, 64(9), 1996, pp. 3833-3844

Abstract

The highly attenuated NYVAC vaccinia virus strain has been utilized to develop a multiantigen, multistage vaccine candidate for malaria, a disease that remains a serious global health problem and for which no highly effective vaccine exists. Genes encoding seven Plasmodium falciparum antigens derived from the sporozoite (circumsporozoite protein and sporozoite surface protein 2), liver (liver stage antigen 1), blood(merozoite surface protein 1, serine repeat antigen, and apical membrane antigen 1), and sexual (25-kDa sexual-stage antigen) stages of theparasite life cycle were inserted into a single NYVAC genome to generate NYVAC-P17. Each of the seven antigens was expressed in NYVAC-Pf7-infected culture cells, and the genotypic and phenotypic stability of the recombinant virus was demonstrated. When inoculated into rhesus monkeys, NYVAC-Pf7 was safe and well tolerated. Antibodies that recognizesporozoites, liver, blood, and sexual stages of P. falciparum were elicited. Specific antibody responses against four of the P. falciparum antigens (circumsporozoite protein, sporozoite surface protein 2, merozoite surface protein 1, and 25-kDa sexual-stage antigen) were characterized. The results demonstrate that NYVAC-Pf7 is an appropriate candidate vaccine for further evaluation in human clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:21:47