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Titolo:
PREDICTION OF RECOVERY OF MYOCARDIAL DYSFUNCTION AFTER REVASCULARIZATION COMPARISON OF F-18 FLUORODEOXYGLUCOSE THALLIUM-201 SPECT, TL-201 STRESS-REINJECTION SPECT AND DOBUTAMINE ECHOCARDIOGRAPHY/
Autore:
BAX JJ; CORNEL JH; VISSER FC; FIORETTI PM; VANLINGEN A; REIJS AEM; BOERSMA E; TEULE GJJ; VISSER CA;
Indirizzi:
FREE UNIV AMSTERDAM HOSP,DEPT CARDIOL,DE BOELELAAN 1117 NL-1081 HV AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT CARDIOL NL-1081 HV AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT NUCL MED NL-1081 HV AMSTERDAM NETHERLANDS ACAD HOSP,DEPT CARDIOL ROTTERDAM NETHERLANDS
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 3, volume: 28, anno: 1996,
pagine: 558 - 564
SICI:
0735-1097(1996)28:3<558:POROMD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; EMISSION COMPUTED-TOMOGRAPHY; LEFT-VENTRICULAR DYSFUNCTION; F-18 FLUORODEOXYGLUCOSE; GLUCOSE-UTILIZATION; VIABLE MYOCARDIUM; TL-201; PET; VIABILITY; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Bax et al., "PREDICTION OF RECOVERY OF MYOCARDIAL DYSFUNCTION AFTER REVASCULARIZATION COMPARISON OF F-18 FLUORODEOXYGLUCOSE THALLIUM-201 SPECT, TL-201 STRESS-REINJECTION SPECT AND DOBUTAMINE ECHOCARDIOGRAPHY/", Journal of the American College of Cardiology, 28(3), 1996, pp. 558-564

Abstract

Objectives. We compared three techniques to predict functional recovery after revascularization. Background. Recently, fluorine-18 (F-18) fluorodeoxyglucose in combination with single-photon emission computed tomography (SPECT) has been proposed to identify viable myocardium, Thallium-201 reinjection and low dose dobutamine echocardiography are used routinely for this purpose. Methods. Seventeen patients (mean [+/-SD] left ventricular ejection fraction 36 +/- 11%) were studied, Regional and global ventricular function were evaluated before and 3 months after revascularization by echocardiography and radionuclide ventriculography, respectively., Myocardial F-18 fluorodeoxyglucose up take (during hyperinsulinemic glucose clamping) was compared with rest perfusion assessed with early thallium-201 SPECT. On a separate day, low dosedobutamine echocardiography and poststress thallium-201 reinjection SPECT were simultaneously performed. Results. The sensitivities for F-18 fluorodeoxyglucose/thallium-201, thallium-201 reinjection and low dose dobutamine echocardiography to assess recovery were 89%, 93% and 85%, respectively; specificities were 77%, 43% and 63%, respectively, Stepwise logistic regression indicated that F-18 fluorodeoxyglucose/ thallium-201 was the best predictor, In hypokinetic segments, the combination of F-18 fluorodeoxyglucose/thallium-201 and low dose dobutamine echocardiography was the best predictor, Global function improved (leftventricular ejection fraction increased >5%) in 6 patients and remained unchanged in 11. All three techniques correctly identified five of six patients with improvement, Fluorine-18 fluorodeoxyglucose/thallium-201 identified all patients without improvement; low dose dobutamine echocardiography identified 9 of 11 without improvement; and thallium-201 reinjection identified 6 of 11 patients without improvement. Conclusions. Fluorine-18 fluorodeoxyglucose/thallium-201 SPECT was superiorto the other techniques in assessing functional recovery. Integrationof metabolic and functional data is necessary, particularly in hypokinesia, for optimal prediction of improvement of regional function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:59:05