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Titolo:
SYSTEMIC T CELL-INDEPENDENT TUMOR-IMMUNITY AFTER TRANSPLANTATION OF UNIVERSAL RECEPTOR-MODIFIED BONE-MARROW INTO SCID MICE
Autore:
HEGE KM; COOKE KS; FINER MH; ZSEBO KM; ROBERTS MR;
Indirizzi:
CELL GENESYS INC,DEPT IMMUNOL & CELL BIOL FOSTER CITY CA 94404 CELL GENESYS INC,DEPT IMMUNOL & CELL BIOL FOSTER CITY CA 94404
Titolo Testata:
The Journal of experimental medicine
fascicolo: 6, volume: 184, anno: 1996,
pagine: 2261 - 2269
SICI:
0022-1007(1996)184:6<2261:STCTAT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM-CELLS; FC-EPSILON-RI; IMMUNODEFICIENCY-VIRUS TYPE-1; NATURAL-KILLER-CELLS; GENE-THERAPY; SIGNAL TRANSDUCTION; GAMMA-CHAIN; INTRACELLULAR IMMUNIZATION; MONOCLONAL-ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Hege et al., "SYSTEMIC T CELL-INDEPENDENT TUMOR-IMMUNITY AFTER TRANSPLANTATION OF UNIVERSAL RECEPTOR-MODIFIED BONE-MARROW INTO SCID MICE", The Journal of experimental medicine, 184(6), 1996, pp. 2261-2269

Abstract

Gene modification of hematopoietic stem cells (HSC) with antigen-specific, chimeric, or ''universal'' immune receptors (URs) is a novel butuntested form of targeted immunotherapy. A human immunodeficiency virus (HIV) envelope-specific UR consisting of the extracellular domain of human CD4 linked to the zeta chain of the T cell receptor (CD4 zeta)was introduced ex vivo into murine HSC by retroviral transduction. After transplantation into immunodeficient SCID mice, sustained high level expression of CD4 zeta was observed in circulating myeloid and natural killer cells. CD4 zeta-transplanted mice were protected from challenge with a lethal dose of a disseminated human leukemia expressing HIV envelope. These results demonstrate the ability of chimeric receptors bearing zeta-signaling domains to activate non-T cell effector populations in vivo and thereby mediate systemic immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:49:06