Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXPRESSION OF AVIAN GLYPICAN IS DEVELOPMENTALLY-REGULATED
Autore:
NIU S; ANTIN PB; AKIMOTO K; MORKIN E;
Indirizzi:
UNIV ARIZONA,CTR HEART,1501 N CAMPBELL AVE,ROOM 6301,POB 245046 TUCSON AZ 85724 UNIV ARIZONA,CTR HEART TUCSON AZ 85724 UNIV ARIZONA,PHYSIOL SCI PROGRAM TUCSON AZ 85724 UNIV ARIZONA,DEPT ANIM SCI TUCSON AZ 85724 UNIV ARIZONA,DEPT PHARMACOL TUCSON AZ 85724 UNIV ARIZONA,DEPT MED TUCSON AZ 85724
Titolo Testata:
Developmental dynamics
fascicolo: 1, volume: 207, anno: 1996,
pagine: 25 - 34
SICI:
1058-8388(1996)207:1<25:EOAGID>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARAN-SULFATE PROTEOGLYCAN; FIBROBLAST GROWTH-FACTOR; APICAL ECTODERMAL RIDGE; NERVOUS-SYSTEM; LIMB DEVELOPMENT; FACTOR RECEPTOR; CHONDROITIN SULFATE; ENDOTHELIAL-CELLS; FGF-RECEPTOR; MOUSE EMBRYO;
Keywords:
CHICK EMBRYO; DEVELOPMENT; GLYPICAN; HSPG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
S. Niu et al., "EXPRESSION OF AVIAN GLYPICAN IS DEVELOPMENTALLY-REGULATED", Developmental dynamics, 207(1), 1996, pp. 25-34

Abstract

An avian cDNA homologue of human and rat glypicans has been cloned from a stage 17 chicken heart cDNA library and used to analyze the distribution of this proteoglycan during development by Northern analysis and whole mount in situ hybridization. At stages 7-12, strong signals were detected in the cephalic region of the neural folds, rostral portion of paraxial mesoderm, and newly formed epithelial somites. At stages 20-25, strong expression was observed in the mantle zone of the telencephalon, the apical epidermal ridge and proximal region of developing limb. Transcripts also were found in the truncus arteriosus and arteriovenous-canal region of the heart, but not in the myocardium. This distribution pattern suggests that the avian glypican may be involved in the morphogenesis of limb, somite, heart, and brain. The expression of glypican also overlaps FGFs in limb bud, FGF receptors in heart andsomite, and NGF receptors in forebrain. The affinity of heparan sulfate proteoglycans for growth factors and the distribution of the avian glypican are consistent with a role for this molecule in growth factor-mediated signals. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:29:37