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Titolo:
PCR-BASED GENOTYPING FOR DUPLICATED AND DELETED CYP2D6 GENES
Autore:
JOHANSSON I; LUNDQVIST E; DAHL ML; INGELMANSUNDBERG M;
Indirizzi:
KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS S-17177 STOCKHOLM SWEDEN KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS S-17177 STOCKHOLM SWEDEN HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT MED LAB SCI & TECHNOL,DIV CLIN PHARMACOL S-14186 HUDDINGE SWEDEN
Titolo Testata:
Pharmacogenetics
fascicolo: 4, volume: 6, anno: 1996,
pagine: 351 - 355
SICI:
0960-314X(1996)6:4<351:PGFDAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POOR METABOLIZERS; DEBRISOQUINE; AMPLIFICATION; POPULATION; LONG;
Keywords:
LONG PCR; SPARTEINE; NEUROLEPTICS; TRICYCLIC ANTIDEPRESSANTS; GENE AMPLIFICATION; GENE DUPLICATION; DEBRISOQUINE; CYTOCHROME P450;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
I. Johansson et al., "PCR-BASED GENOTYPING FOR DUPLICATED AND DELETED CYP2D6 GENES", Pharmacogenetics, 6(4), 1996, pp. 351-355

Abstract

The debrisoquine hydroxylase (CYP2D6), which metabolizes more than 30different drugs, is highly polymorphic, In subjects having either very low or very high enzyme activity, drug therapy at recommended doses using CYP2D6 substrates may lead to either increased risk of side effects or therapeutic failure, We here describe PCR-based methods for detection of alleles having either duplicated, multiduplicated or deletedactive CYP2D6 genes, As a control reaction, the entire coding region of the CYP2D6 gene is amplified. In conjunction with analysis of common mutations using this product as a template, the methods described can be used for genotyping of individuals being either poor, intermediate rapid, normal or ultrarapid metabolizers and provides an efficient tool for individualization of drug therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:58:36