Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXON AND INTRON VARIANTS IN THE HUMAN TRYPTOPHAN 2,3-DIOXYGENASE GENE- POTENTIAL ASSOCIATION WITH TOURETTE SYNDROME, SUBSTANCE-ABUSE AND OTHER DISORDERS
Autore:
COMINGS DE; GADE R; MUHLEMAN D; CHIU C; WU SJ; TO M; SPENCE M; DIETZ G; WINNDEEN E; ROSENTHAL RJ; LESIEUR HR; RUGLE L; SVERD J; FERRY L; JOHNSON JP; MACMURRAY JP;
Indirizzi:
CITY HOPE NATL MED CTR,DEPT MED GENET,1500 E DUARTE RD DUARTE CA 91010 PERKIN ELMER CORP,APPL BIOSYST DIV FOSTER CITY CA 94404 UNIV CALIF LOS ANGELES,DEPT PSYCHIAT LOS ANGELES CA 90021 ILLINOIS STATE UNIV,DEPT CRIMINAL JUSTICE SCI NORMAL AL 00000 DEPT VET AFFAIRS MED CTR,VET ADDICT RECOVERY CTR BRECKSVILLE OH 00000 SAGAMORE CHILDRENS HOSP DIX HILLS NY 11746 LOMA LINDA UNIV,JERRY L PETTIS MEM VET HOSP LOMA LINDA CA 92357
Titolo Testata:
Pharmacogenetics
fascicolo: 4, volume: 6, anno: 1996,
pagine: 307 - 318
SICI:
0960-314X(1996)6:4<307:EAIVIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD SEROTONIN; ALCOHOL INTAKE; SEQUENCE; DEPENDENCE; RELATIVES; MUTATIONS; PROBANDS; CHILDREN;
Keywords:
OXYGENASE; TRYPTOPHAN; SEROTONIN; POLYMORPHISM; TRYPTOPHAN 2,3 DIOXYGENASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Comings et al., "EXON AND INTRON VARIANTS IN THE HUMAN TRYPTOPHAN 2,3-DIOXYGENASE GENE- POTENTIAL ASSOCIATION WITH TOURETTE SYNDROME, SUBSTANCE-ABUSE AND OTHER DISORDERS", Pharmacogenetics, 6(4), 1996, pp. 307-318

Abstract

Defects in serotonin metabolism, and abnormalities in both blood serotonin and tryptophan levels, have been reported in many psychiatric disorders, Tryptophan 2,3-dioxygenase (TDO2) is the rate limiting enzymefor the breakdown of tryptophan to N-formyl kenurenine, Functional variants of this gene could account for the observed simultaneous increases or decreases of both serotonin and tryptophan in various disorders, We have identified four different polymorphisms of the human TDO2 gene, Association studies show a significant association of one or more of these polymorphisms and Tourette syndrome (TS), attention deficit hyperactivity disorder (ADHD) and drug dependence, The intron 6(G-->T) variant was significantly associated with platelet serotonin levels, Only the association with TS was significant with a Bonferroni correction (p=0.005), Our purpose here is not to claim these associations are proven, but rather to report preliminary results and show that easily testable polymorphisms are available, We hope to encourage additional research into the potential role the TDO2 gene in these and other psychiatric disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:19:00