Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ISOLATION AND CHARACTERIZATION OF SUG2 - A NOVEL ATPASE FAMILY COMPONENT OF THE YEAST 26 S PROTEASOME
Autore:
RUSSELL SJ; SATHYANARAYANA UG; JOHNSTON SA;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,GRAD PROGRAM BIOCHEM & MOL BIOL,MOL CARDIOL LABS DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,GRAD PROGRAM BIOCHEM & MOL BIOL,MOL CARDIOL LABS DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,GRAD PROGRAM BIOCHEM & MOL BIOL DALLAS TX 75235
Titolo Testata:
The Journal of biological chemistry
fascicolo: 51, volume: 271, anno: 1996,
pagine: 32810 - 32817
SICI:
0021-9258(1996)271:51<32810:IACOS->2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAT-BINDING-PROTEIN; SACCHAROMYCES-CEREVISIAE; GAL4 PROTEIN; GALACTOSE; ACTIVATION; GENE; TRANSFORMATION; DEGRADATION; MEDIATOR; REGULON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Russell et al., "ISOLATION AND CHARACTERIZATION OF SUG2 - A NOVEL ATPASE FAMILY COMPONENT OF THE YEAST 26 S PROTEASOME", The Journal of biological chemistry, 271(51), 1996, pp. 32810-32817

Abstract

Using a genetic strategy designed to find proteins involved in the function of the Saccharomyces cerevisiae transcriptional activator GAL4,we isolated mutants in two genes which rescue a class of gal4 activation domain mutants. One of these genes, SUG1, encodes a member of a large family of putative ATPases, the (C) under bar onserved (A) under bar TPase containing (D) under bar omain (CAD) proteins (also known as AAA proteins) that are involved in a wide variety of cellular functions. Subsequently, SUG1 was identified as a subunit of the 26 S proteasome. We have now cloned the gene defined by the second complementation group. SUG2 encodes an essential 49-kDa protein that is also a member of the CAD family and is 43% identical to SUG1. The mutation in sug2-1, like that in sug1-1, is found in the CAD near the highly conserved ATPase motif. We present biochemical and genetic evidence that SUG2 is associated in vivo with SUG1 and is a novel CAD protein subunit of the26 S proteasome. With its highly con served mammalian homologs, humanp42 and ground squirrel CADp44, SUG2 defines a new class of proteasomal CAD proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 01:15:25