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Titolo:
PENTAGASTRIN HAS PANIC INDUCING PROPERTIES IN OBSESSIVE-COMPULSIVE DISORDER
Autore:
DELEEUW AS; DENBOER JA; SLAAP BR; WESTENBERG HGM;
Indirizzi:
ACAD HOSP GRONINGEN,DEPT PSYCHIAT,HANZEPLEIN 1,POB 30001 NL-9700 RB GRONINGEN NETHERLANDS ACAD HOSP GRONINGEN,DEPT PSYCHIAT NL-9700 RB GRONINGEN NETHERLANDS ACAD HOSP UTRECHT,DEPT PSYCHIAT NL-3508 GA UTRECHT NETHERLANDS
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 126, anno: 1996,
pagine: 339 - 344
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ-TETRAPEPTIDE; HEALTHY-VOLUNTEERS; NEUROENDOCRINE RESPONSES; M-CHLOROPHENYLPIPERAZINE; NORADRENERGIC FUNCTION; ENHANCED SENSITIVITY; SEROTONIN AGONIST; LACTATE INFUSIONS; ATTACKS; ANXIETY;
Keywords:
CCK-B RECEPTOR; PENTAGASTRIN; OBSESSIVE COMPULSIVE DISORDER; PANIC ATTACKS; PLASMA MHPG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Deleeuw et al., "PENTAGASTRIN HAS PANIC INDUCING PROPERTIES IN OBSESSIVE-COMPULSIVE DISORDER", Psychopharmacology, 126(4), 1996, pp. 339-344

Abstract

The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 mu g/kg pentagastrin or placebo under double blind placebo controlled conditions, on two separate occasions, with a minimum interval of 1 week. Six (86%) out of seven OCD patients experienced a panic-like reaction after pentagastrin administration, against only two (29%) in the control group. These differences failed to reach statistical significance, probably due to the small sample size. No increases were observed in obsessions or compulsive behaviors as assessed with the Yale-Brown Obsessive Compulsive Challenge Scale, neither in the pentagastrin,nor in the placebo condition. These findings suggest that pentagastrin has panic-inducing properties in OCD patients, without affecting thecore symptoms. The panic-inducing properties of pentagastrin are not specific for panic disorder patients, which might be indicative of a common neurobiological dysfunction in panic disorder and OCD at the level of CCK-B receptors.

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Documento generato il 02/04/20 alle ore 12:48:41