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Titolo:
SEROTONERGIC MODULATION OF STRIATAL D-2 DOPAMINE-RECEPTOR BINDING IN HUMANS MEASURED WITH POSITRON EMISSION TOMOGRAPHY
Autore:
TIIHONEN J; KUOPPAMAKI M; NAGREN K; BERGMAN J; ERONEN E; SYVALAHTI E; HIETALA J;
Indirizzi:
UNIV KUOPIO,NIUVANNIEMI HOSP,DEPT FORENS PSYCHIAT FIN-70240 KUOPIO FINLAND TURKU UNIV,DEPT PHARMACOL FIN-20520 TURKU FINLAND TURKU UNIV,CENT HOSP,TURKU MED CYCLOTRON PET CTR FIN-20520 TURKU FINLAND ABO AKAD UNIV,ACCELERATOR LAB TURKU FINLAND TURKU UNIV,CENT HOSP,DEPT PSYCHIAT FIN-20520 TURKU FINLAND
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 126, anno: 1996,
pagine: 277 - 280
Fonte:
ISI
Lingua:
ENG
Soggetto:
NAIVE SCHIZOPHRENIC-PATIENTS; IN-VIVO; PET; MICRODIALYSIS; RACLOPRIDE; C-11;
Keywords:
POSITRON EMISSION TOMOGRAPHY; DOPAMINE; SEROTONIN; RACLOPRIDE; INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
J. Tiihonen et al., "SEROTONERGIC MODULATION OF STRIATAL D-2 DOPAMINE-RECEPTOR BINDING IN HUMANS MEASURED WITH POSITRON EMISSION TOMOGRAPHY", Psychopharmacology, 126(4), 1996, pp. 277-280

Abstract

The modulating effect of serotonergic drugs on the striatal dopamine neurotransmission has remained controversial, and there are no published data on serotonin-dopamine interaction obtained from living human brain. Citalopram is a selective serotonin reuptake inhibitor widely used in the treatment of depression (20-40 mg/day). We measured the effects of acute (20 mg, per os) and chronic (20 mg/day for 14 days) dosesof citalopram and placebo intake on [C-11]-raclopride binding to striatal D-2-receptors in eight healthy volunteers by using positron emission tomography. Although the effect magnitude was not large, the results indicate that chronic citalopram intake slightly decreases the raclopride binding which may reflect increased dopamine release in the striatum. In addition, after 14 days there was a high correlation betweenthe citalopam plasma levels and the decrease in the [C-11]-raclopridebinding in both the caudate and the putamen, although statistically significant effect in the raclopride binding potential was more pronounced in the putamen. This report suggests functional interaction of brain dopaminergic and serotonergic systems in vivo in man.

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Documento generato il 20/01/20 alle ore 16:55:23