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Titolo:
AN INVESTIGATION INTO THE REVERSIBILITY OF THE MORPHOLOGICAL AND CYTOKINETIC CHANGES SEEN IN THE SMALL-INTESTINE OF RIBOFLAVIN DEFICIENT RATS
Autore:
WILLIAMS EA; RUMSEY RDE; POWERS HJ;
Indirizzi:
UNIV SHEFFIELD,SHEFFIELD CHILDRENS HOSP,DEPT PAEDIAT,WESTERN BANK SHEFFIELD S10 2TH S YORKSHIRE ENGLAND UNIV SHEFFIELD,SHEFFIELD CHILDRENS HOSP,DEPT PAEDIAT,WESTERN BANK SHEFFIELD S10 2TH S YORKSHIRE ENGLAND UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN S YORKSHIRE ENGLAND
Titolo Testata:
Gut
fascicolo: 2, volume: 39, anno: 1996,
pagine: 220 - 225
SICI:
0017-5749(1996)39:2<220:AIITRO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROCYTE GLUTATHIONE-REDUCTASE; MOUSE SMALL-INTESTINE; IRON; VILLI; ABSORPTION; MECHANISM; DEPLETION; KINETICS; ADULT;
Keywords:
RIBOFLAVIN DEPLETION AND REPLETION; INTESTINAL MORPHOLOGY; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Williams et al., "AN INVESTIGATION INTO THE REVERSIBILITY OF THE MORPHOLOGICAL AND CYTOKINETIC CHANGES SEEN IN THE SMALL-INTESTINE OF RIBOFLAVIN DEFICIENT RATS", Gut, 39(2), 1996, pp. 220-225

Abstract

Background-Impaired iron handling in riboflavin deficiency is thoughtto be partially a result of significant morphological and cytokineticchanges within the small intestine. Aims-The aim of the study was to find out if the responses of the rat small intestine to riboflavin deficiency induced at weaning could be reversed upon repletion. Subjects-48 female weanling Wistar rats were used for the purpose of the study. Methods-Rats were fed a riboflavin deficient diet or a complete control diet for a period of five weeks followed by a repletion period of up to three weeks. Rats were killed on day 0, 2, 7, or 21 of repletion. The duodenum was removed and fixed for subsequent analysis. Results-Five weeks of riboflavin deficiency significantly changed the morphology and cytokinetics of the duodenum; the changes were not reversed within the 21 day repletion period despite biochemical evidence for a correction of the deficiency. Conclusions-The results show that the small intestine cannot readily recover from a period of riboflavin deficiency induced at weaning, supporting the notion that the weaning period isa critical time for gastrointestinal development and highlighting theimportance of adequate nutrition during infancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:14:44