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Titolo:
BEHAVIORAL AND ANALGESIC EFFECTS INDUCED BY ADMINISTRATION OF NIFEDIPINE AND NIMODIPINE
Autore:
MARTIN MI; DELVAL VL; COLADO MI; GOICOECHEA C; ALFARO MJ;
Indirizzi:
UNIV COMPLUTENSE MADRID,FAC MED,DEPT FARMACOL E-28040 MADRID SPAIN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 55, anno: 1996,
pagine: 93 - 98
SICI:
0091-3057(1996)55:1<93:BAAEIB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-CHANNEL BLOCKERS; ELEVATED PLUS-MAZE; WITHDRAWAL SYNDROME; OPIOID RECEPTORS; BLOCKING-AGENTS; RATS; ANTAGONISTS; MORPHINE; VERAPAMIL; MICE;
Keywords:
NIFEDIPINE; NIMODIPINE; BEHAVIOR; PAIN; ANALGESIA; ANXIETY; HOLEBOARD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Martin et al., "BEHAVIORAL AND ANALGESIC EFFECTS INDUCED BY ADMINISTRATION OF NIFEDIPINE AND NIMODIPINE", Pharmacology, biochemistry and behavior, 55(1), 1996, pp. 93-98

Abstract

Evidence exists that calcium antagonists can have effects on neural function. The aim of this work is to analyze the effect of two dihydropyridines, nifedipine and nimodipine, administered for 11 days on the behavior and pain sensitivity of rats. Nociception was tested using thetail electric stimulation test, and behavior parameters using a holeboard. Our results show that chronic administration of nifedipine or nimodipine induces analgesia that can be evaluated by tail withdrawal. However, neither the vocalization nor the vocalization after discharge were modified, so the analgesia may be mediated by spinal mechanisms. Rats treated with nifedipine or nimodipine exhibited a dose-dependent tendency to avoid the center of the held without modification of otherparameters, suggesting an increased emotivity in the rats. This conclusion is supported by the fact that anxiogenic or anxiolytic drugs modify the pattern of locomotion without significant changes in other parameters related with the motility. The results from this study suggestthe view of a complex mechanism of action underlying nifedipine- and nimodipine-mediated behavioral effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:23:05