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Titolo:
THE GENETIC TOXICITY OF SYNTHETIC CHEMICALS .2. A PYRETHROID INSECTICIDE, FENPROPATHRIN
Autore:
RYU JC; KIM KR; KIM HJ; RYU EK; LEE SY; JUNG SO; YOUN JY; KIM MH; KWON OS;
Indirizzi:
KOREA ADV INST SCI & TECHNOL,DOPING CONTROL CTR,TOXICOL LAB,POB 131 SEOUL 130650 SOUTH KOREA
Titolo Testata:
Archives of pharmacal research
fascicolo: 4, volume: 19, anno: 1996,
pagine: 251 - 257
SICI:
0253-6269(1996)19:4<251:TGTOSC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD RETICULOCYTES; MICRONUCLEUS ASSAY; MUTAGENICITY TEST; TRANSGENIC MICE; SOS CHROMOTEST; CARCINOGENS; ELECTROPHORESIS; MUTATIONS; INVITRO; CELLS;
Keywords:
GENOTOXICITY; CLASTOGENICITY; FENPROPATHRIN; SALMONELLA TYPHIMURIUM; CHROMOSOMAL ABERRATION; MICRONUCLEUS; CHINESE HAMSTER LUNG FIBROBLAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Ryu et al., "THE GENETIC TOXICITY OF SYNTHETIC CHEMICALS .2. A PYRETHROID INSECTICIDE, FENPROPATHRIN", Archives of pharmacal research, 19(4), 1996, pp. 251-257

Abstract

The detection of many synthetic chemicals used in industry that may pose a genetic hazard in our environment is subject of great concern atpresent. In this respect, the genetic toxicity of fenpropathrin S)-alpha-cyano-3-phenoxybenzyl-2,2,3,3-tetramethyl cyclopropane carboxylate, CAS No.: 39515-41-8), a pyrethroid insecticide, was evaluated in bacterial gene mutation system, chromosome aberration in mammalian cell system and in vivo micronucleus assay with rodents. In bacterial gene mutation assay, no mutagenicity of fenpropathrin (62-5000 mu g/plate) was observed in Salmonella typhimurium TA 98, 100, 1535 and 1537 both in the absence and in the presence of S-9 metabolic activation system. In mammalian cell system using chinese hamster lung fibroblast, no clastogenicity of fenpropathrin was also observed both in the absence andin the presence of metabolic activation system in the concentration range of 7-28 mu g/ml. And also, in vivo micronucleus assay using mousebone marrow cells, fenpropathrin also revealed no mutagenic potentialin the dose range of 27-105 mg/kg body weight of fenpropathrin (i.p.). Consequently, no mutagenic potential of fenpropathrin was observed in vitro bacterial, mammalian mutagenicity systems and in vivo micronucleus assay in the dose ranges used in this experiment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 11:40:04