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Titolo:
DECREASED INTERLEUKIN-10 PRODUCTION BY NEONATAL MONOCYTES AND T-CELLS- RELATIONSHIP TO DECREASED PRODUCTION AND EXPRESSION OF TUMOR-NECROSIS-FACTOR-ALPHA AND ITS RECEPTORS
Autore:
CHHEDA S; PALKOWETZ KH; GAROFALO R; RASSIN DK; GOLDMAN AS;
Indirizzi:
UNIV TEXAS,MED BRANCH,DEPT PEDIAT,DIV NEONATOL,ROOM 6104,R WAVERLEY SMITH PAVIL,301 UNIV BLVD GALVESTON TX 77555
Titolo Testata:
Pediatric research
fascicolo: 3, volume: 40, anno: 1996,
pagine: 475 - 483
SICI:
0031-3998(1996)40:3<475:DIPBNM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA-PRODUCTION; HUMAN CORD-BLOOD; MONONUCLEAR-CELLS; POLYMORPHONUCLEAR LEUKOCYTES; NECROTIZING ENTEROCOLITIS; DEFECTIVE PRODUCTION; CYTOKINE PRODUCTION; FACTOR CACHECTIN; NEWBORN-INFANTS; GENE-EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
S. Chheda et al., "DECREASED INTERLEUKIN-10 PRODUCTION BY NEONATAL MONOCYTES AND T-CELLS- RELATIONSHIP TO DECREASED PRODUCTION AND EXPRESSION OF TUMOR-NECROSIS-FACTOR-ALPHA AND ITS RECEPTORS", Pediatric research, 40(3), 1996, pp. 475-483

Abstract

The production of IL-10 by human neonatal blood mononuclear leukocytes (BML) stimulated with lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), antibodies to CD3, or phorbol 12-myristate 13-acetate (PMA) was measured. The production of IL-10 by neonatal BML cultured with LPS or TNF-alpha was similar to 20 and similar to 15%, respectively, of adult BML. The combination of human recombinant TNF-alpha and LPS failed to augment IL-10 production in neonatal BML. The decreased production of IL-10 by neonatal leukocytes was not due to an autocrine feedback mechanism because only low concentrations of IL-10 were found in newborn sera. A connection with TNF-alpha could not be ruled out, because TNF-alpha production by LPS-stimulated newborn BML and theexpression of TNF-alpha receptors on newborn monocytes were reduced. Mean +/- SD of concentrations of IL-10 in supernatants from adult and neonatal BML after stimulation with antibodies to human CD3 for 48 or 72 h were 914 +/- 386 and 178 +/- 176 pg/mL, respectively (p < 0.0001). Ln experiments with enriched populations of neonatal T cells, the addition of PMA failed to augment IL-10 production. This suggested that newborn T cells may be in a different state of activation than adult Tcells Thus, IL-10 production in neonatal monocytes and T cells is reduced and this study suggests that the reduction may be secondary in part to regulatory processes involving TNF-alpha and its receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:19:44