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Titolo:
ONSET OF PROTECTIVE IMMUNITY IN CHICKS AFTER VACCINATION WITH A RECOMBINANT HERPESVIRUS OF TURKEYS VACCINE EXPRESSING NEWCASTLE-DISEASE VIRUS FUSION AND HEMAGGLUTININ-NEURAMINIDASE ANTIGENS
Autore:
HECKERT RA; RIVA J; COOK S; MCMILLEN J; SCHWARTZ RD;
Indirizzi:
AGR & AGRI FOOD CANADA,ANIM DIS RES INST,3851 FALLOWFIELD RD,POB 11300,STN H NEPEAN ON K2H 8P9 CANADA SYNTRO CORP SAN DIEGO CA 92121 SYNTROVET INC LENEXA KS 66219 HOECHST ROUSSEL AGRIVET CO SOMERVILLE NJ 08876
Titolo Testata:
Avian diseases
fascicolo: 4, volume: 40, anno: 1996,
pagine: 770 - 777
SICI:
0005-2086(1996)40:4<770:OOPIIC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-SEQUENCE; FOWLPOX VIRUS; GENE; GLYCOPROTEIN; PROTEIN;
Keywords:
NEWCASTLE DISEASE; HVT; RECOMBINANT VACCINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Heckert et al., "ONSET OF PROTECTIVE IMMUNITY IN CHICKS AFTER VACCINATION WITH A RECOMBINANT HERPESVIRUS OF TURKEYS VACCINE EXPRESSING NEWCASTLE-DISEASE VIRUS FUSION AND HEMAGGLUTININ-NEURAMINIDASE ANTIGENS", Avian diseases, 40(4), 1996, pp. 770-777

Abstract

The onset of protective immunity from lethal Newcastle disease virus (NDV) challenge of chicks was determined after vaccination with a recombinant herpes virus of turkeys (HVT) expressing the fusion and hemagglutinin-neuraminidase proteins of NDV. One-day-old specific-pathogen-free chicks devoid of maternal antibodies to NDV were vaccinated with 130 to 3300 plaque forming units of HVT (depending on the trial) and then challenged at 4, 7, 10, and 14 days postvaccination (DPV) with a neurotropic velogenic strain of NDV (GB Texas). The recombinant vaccine afforded 0%, 35-75%, 85%, and 94-100% protection when the vaccinated birds were challenged at 4, 7, 10, and 14 DPV, respectively. In all trials, challenge caused 100% mortality in unvaccinated control chicks. Newcastle disease virus was reisolated from the lung, liver, spleen, and brain of birds dying in all trials regardless of vaccine dosage or time of challenge, except when challenge occurred at 14 DPV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 00:48:13