Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMPROVED OUTCOME IN PATIENTS TREATED WITH POSTOPERATIVE RADIATION-THERAPY FOR PATHOLOGICAL STAGE WITH ENDOMETRIAL CANCER
Autore:
ALGAN O; TABESH T; HANLON A; HOGAN WM; BOENTE M; LANCIANO RM;
Indirizzi:
FOX CHASE CANC CTR,DEPT RADIAT ONCOL,7701 BURHOLME AVE PHILADELPHIA PA 19111 FOX CHASE CANC CTR,DEPT GYNECOL ONCOL PHILADELPHIA PA 19111
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 5, volume: 35, anno: 1996,
pagine: 925 - 933
SICI:
0360-3016(1996)35:5<925:IOIPTW>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
II CARCINOMA; EXTERNAL IRRADIATION; VAGINAL IRRADIATION; PROGNOSTIC FACTORS; ADENOCARCINOMA; COMPLICATIONS; RADIOTHERAPY; SURVIVAL; SYSTEM;
Keywords:
HIGH-RISK ENDOMETRIAL CANCER; EXTERNAL PELVIC IRRADIATION; BRACHYTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
O. Algan et al., "IMPROVED OUTCOME IN PATIENTS TREATED WITH POSTOPERATIVE RADIATION-THERAPY FOR PATHOLOGICAL STAGE WITH ENDOMETRIAL CANCER", International journal of radiation oncology, biology, physics, 35(5), 1996, pp. 925-933

Abstract

Purpose: To evaluate prognostic factors and treatment outcome for high risk pathological Stage I and II endometrial cancer patients treatedwith consistent postoperative radiation therapy (RT) in a single institution and to compare these results to series where RT was variably applied. Methods and Material: Between 1986 and 1993, 98 pathologic Stage I and II endometrial cancer patients received postoperative RT at the Fox Chase Cancer Center. Papillary serous and clear cell histologies were excluded. Fifty-five patients underwent lymph node evaluation. In 17 patients, RT consisted of intracavitary brachytherapy alone to amedian dose of 21 Gy, and in 81 patients, RT consisted of external beam RT to a median dose of 45 Gy followed by intracavitary brachytherapy to a median dose of 12 Gy. Intracavitary brachytherapy generally consisted of three high dose rate implants with the dose prescribed to a depth of 0.5 cm. Median follow up was 47 months. Results: The 5-year overall survival (OS), disease free survival (DFS), and freedom from pelvic recurrence (FPR) rates were 83, 85, and 89%, respectively. Pelvicrecurrence either as the sole pattern of failure or combined with distant metastases was seen in 2 and 7% of patients, respectively. Distant metastases alone occurred in 4% of the patients. Univariate analysisof prognostic factors including age, grade, capillary lymphatic spaceinvasion, depth of myometrial invasion, type of lymph node evaluation, pathologic stage, the use of brachytherapy and the number of risk factors was performed for OS, DFS, FPR, and FDM. Capillary lymphatic space invasion was the only statistically significant predictor for reduced DFS. Absence of lymph node dissection as well as a higher number ofrisk factors showed a trend toward poorer DFS (p = 0.06 for both). Multivariate analysis revealed older age to be the only factor significant for reduced DFS, with the presence of capillary lymphatic space invasion and the absence of a lymph node dissection showing a trend toward poorer outcome (p = 0.07). Conclusions: The results of this study suggest a continued role for the use of postoperative RT in the treatment of patients with high risk endometrial cancer and will be compared to other series with similar high-risk factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:25:14