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Titolo:
AUTOLOGOUS GRANULOSA-CELL COCULTURE DEMONSTRATES ZYGOTE SUPPRESSION OF GRANULOSA-CELL STEROIDOGENESIS
Autore:
SEIFER DB; FREEMAN MR; GARDINER AC; HILL GA; SCHNEYER AL; VANDERHYDEN BC;
Indirizzi:
UNIV OTTAWA,OTTAWA REG CANC CTR,CANC RES LABS,3RD FLOOR,501 SMYTH RD OTTAWA ON K1H 8L6 CANADA UNIV OTTAWA,OTTAWA REG CANC CTR,CANC RES LABS OTTAWA ON K1H 8L6 CANADA BROWN UNIV,WOMEN & INFANTS HOSP RHODE ISL,SCH MED PROVIDENCE RI 02908 CENTENNIAL MED CTR,CTR ASSISTED REPROD & REPROD ENDOCRINOL NASHVILLE TN 00000 MASSACHUSETTS GEN HOSP,REPROD ENDOCRINE UNIT BOSTON MA 02114 MASSACHUSETTS GEN HOSP,NATL CTR INFERTIL RES BOSTON MA 02114
Titolo Testata:
Fertility and sterility
fascicolo: 3, volume: 66, anno: 1996,
pagine: 425 - 429
SICI:
0015-0282(1996)66:3<425:AGCDZS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYALURONIC-ACID SYNTHESIS; TUMOR-NECROSIS-FACTOR; MOUSE OOCYTES; ACTIVIN-A; PREIMPLANTATION DEVELOPMENT; CUMULUS CELLS; INVITRO; EXPANSION; PROGESTERONE; CYTOKINE;
Keywords:
GRANULOSA CELL STEROIDOGENESIS; AUTOLOGOUS GRANULOSA CELL COCULTURE; EMBRYO DEVELOPMENT; ESTRADIOL; PROGESTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Seifer et al., "AUTOLOGOUS GRANULOSA-CELL COCULTURE DEMONSTRATES ZYGOTE SUPPRESSION OF GRANULOSA-CELL STEROIDOGENESIS", Fertility and sterility, 66(3), 1996, pp. 425-429

Abstract

Objective: To determine if embryos can modulate steroid hormone production by luteinized granulosa cells. Design: Granulosa cells obtained from follicular aspirates were cultured alone or in the presence of a two-pronuclear zygote. The production of E(2) and P by these cultures was evaluated by RIA. Setting: In Vitro Fertilization Unit in an academic research environment. Patients: Sixteen women undergoing IVF. Interventions: Standard IVF-ET treatment cycle using leuprolide acetate for pituitary desensitization before hMG or urofollitropin for ovarian stimulation. Main Outcome Measures: Estradiol and P concentration in culture media of luteinized granulosa cells alone or granulosa cells cocultured with a two-pronuclear embryo. Results: Both E(2) and P production by luteinized granulosa cells was reduced when cultured in the presence of an embryo. Conclusions: Human embryos secrete a factor that regulates granulosa cell steroidogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 07:32:49