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Titolo:
DESIGN CONSIDERATIONS AND INITIAL PERFORMANCE OF A 1.2 CM(2) BETA IMAGING INTRAOPERATIVE PROBE
Autore:
TORNAI MP; MACDONALD LR; LEVIN CS; SIEGEL S; HOFFMAN EJ;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT MOL & MED PHARMACOL,DIV NUCL MED & BIOPHYS LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,DEPT PHYS LOS ANGELES CA 90095
Titolo Testata:
IEEE transactions on nuclear science
fascicolo: 4, volume: 43, anno: 1996,
parte:, 1
pagine: 2326 - 2335
SICI:
0018-9499(1996)43:4<2326:DCAIPO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT PHOTON COUNTERS; TUMOR-LOCALIZATION; DETECTOR; POSITRON; FIBERS; SURGERY; CAMERAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Tornai et al., "DESIGN CONSIDERATIONS AND INITIAL PERFORMANCE OF A 1.2 CM(2) BETA IMAGING INTRAOPERATIVE PROBE", IEEE transactions on nuclear science, 43(4), 1996, pp. 2326-2335

Abstract

A navel small area beta (beta(+/-)) detector is under development fornuclear emission imaging of surgically exposed, radiolabeled tumor beds. The imaging device front-end consists of a 0.5 mm thick by 1.25 cmdiameter CaF2(Eu) scintillator disk coupled to a rigid bundle of 2 mmdiameter double clad optical fibers through a polystyrene light diffuser. The detector area (1.2 cm(2)) was determined by the requirement of introducing the probe into small cavities, e.g. during neuro-surgical lesion resection, but large enough to produce images of clinical significance. Flexible back-end optical fibers (1.9 m long) were coupled to the front-end components allowing similar to 75 photoelectrons to be detected for mean beta energies of 250 keV, indicating that sufficient signal can be obtained with clinical beta emitters (e.g. F-18, I-131). The long flexible fibers guide the scintillation light to a Philips XP1700 series, fiber optic faceplate, Multi-Channel PMT. The parallel MC-PMT outputs are fed into a variable gain, charge divider network and an i-V pre-amplifier/line driver network, whose resulting four outputs are digitized and histogrammed with standard Anger positioning logic. The various components in the imaging chain were evaluated and optimized by both simulations and measurements. Line spread functions measured in the 10.8 mm FOV were 0.50 mm +/- 0.038 mm and 0.55 mm +/- 0.065 mm FWHM in X and Y, respectively. A 20% variation in pulse height and minimal variation in spatial resolution was observed. The differential image uniformity was measured to be +/-15.6% with similar to 150 cts/pixel. Preliminary images show excellent reproduction of phantom activity distributions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:10:18