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Titolo:
EXAMINATION OF 2 GENETIC POLYMORPHISMS WITHIN THE RENIN-ANGIOTENSIN SYSTEM - NO EVIDENCE FOR AN ASSOCIATION WITH NEPHROPATHY IN IDDM
Autore:
CHOWDHURY TA; DRONSFIELD MJ; KUMAR S; GOUGH SLC; GIBSON SP; KHATOON A; MACDONALD F; ROWE BR; DUNGER DB; DEAN JD; DAVIES SJ; WEBBER J; SMITH PR; MACKIN P; MARSHALL SM; ADU D; MORRIS PJM; TODD JA; BARNETT AH; BOULTON AJM; BAIN SC;
Indirizzi:
UNIV BIRMINGHAM,BIRMINGHAM HEARTLANDS HOSP,CTR DIABET,DEPT MED,WARD 24,BORDESLEY GREEN E BIRMINGHAM B9 5SS W MIDLANDS ENGLAND UNIV BIRMINGHAM,QUEEN ELIZABETH HOSP,DEPT MED BIRMINGHAM B15 2TH W MIDLANDS ENGLAND WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG OXFORD ENGLAND SOUTHMEAD GEN HOSP,RICHARD BRIGHT RENAL UNIT BRISTOL AVON ENGLAND UNIV BIRMINGHAM,BIRMINGHAM HEARTLANDS HOSP,DEPT CLIN GENET BIRMINGHAMB9 5SS W MIDLANDS ENGLAND JOHN RADCLIFFE HOSP,DEPT PAEDIAT OXFORD OX3 9DU ENGLAND BOLTON GEN HOSP,DEPT MED BOLTON ENGLAND ROYAL INFIRM,DEPT RENAL MED STOKE ON TRENT STAFFS ENGLAND MED SCH NEWCASTLE UPON TYNE,DEPT MED NEWCASTLE TYNE NE2 4HH TYNE & WEAR ENGLAND UNIV BIRMINGHAM,QUEEN ELIZABETH HOSP,DEPT NEPHROL BIRMINGHAM B15 2TH W MIDLANDS ENGLAND MANCHESTER ROYAL INFIRM,DEPT MED MANCHESTER M13 9WL LANCS ENGLAND
Titolo Testata:
Diabetologia
fascicolo: 9, volume: 39, anno: 1996,
pagine: 1108 - 1114
SICI:
0012-186X(1996)39:9<1108:EO2GPW>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME GENE; INSERTION DELETION POLYMORPHISM; CORONARY HEART-DISEASE; DIABETIC NEPHROPATHY; BLOOD-PRESSURE; MICROALBUMINURIA; SUSCEPTIBILITY; CARDIOMYOPATHY; HYPERTENSION; MELLITUS;
Keywords:
INSULIN-DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; DIABETIC NEPHROPATHY; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; GENE POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Chowdhury et al., "EXAMINATION OF 2 GENETIC POLYMORPHISMS WITHIN THE RENIN-ANGIOTENSIN SYSTEM - NO EVIDENCE FOR AN ASSOCIATION WITH NEPHROPATHY IN IDDM", Diabetologia, 39(9), 1996, pp. 1108-1114

Abstract

Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n = 242). Three groups were examinedfor comparison: ethnically matched non-diabetic subjects (n = 187); ageographically defined cohort of newly diagnosed diabetic patients (n= 341); and IDDM patients with long duration of disease (> 15 years) and no evidence of overt nephropathy (n = 166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p = 0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p = 0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:20:49