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Titolo:
CARDIAC ELECTROPHYSIOLOGICAL VARIABLES IN BLOOD-PERFUSED AND BUFFER-PERFUSED, ISOLATED, WORKING RABBIT HEART
Autore:
GILLIS AM; KULISZ E; MATHISON HJ;
Indirizzi:
UNIV CALGARY,DEPT MED,CARDIOVASC RES GRP,3330 HOSP DR NW CALGARY AB T2N 4N1 CANADA
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 2, volume: 40, anno: 1996,
pagine: 784 - 789
SICI:
0363-6135(1996)40:2<784:CEVIBA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTION-EXCITATION FEEDBACK; ACUTE VENTRICULAR DILATATION; MECHANOELECTRICAL FEEDBACK; MYOCARDIAL STRETCH; PHARMACODYNAMICS; EXCITABILITY; STABILITY; PRELOAD; ALBUMIN; LOAD;
Keywords:
BLOOD PERFUSATE; VENTRICULAR FIBRILLATION; VENTRICULAR REPOLARIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Gillis et al., "CARDIAC ELECTROPHYSIOLOGICAL VARIABLES IN BLOOD-PERFUSED AND BUFFER-PERFUSED, ISOLATED, WORKING RABBIT HEART", American journal of physiology. Heart and circulatory physiology, 40(2), 1996, pp. 784-789

Abstract

Effects of crystalloid buffer and blood-buffer perfusates on cardiac electrophysiological parameters were compared in four groups of isolated, working rabbit hearts. Hearts were perfused with Krebs-Henseleit buffer or blood plus Krebs-Henseleit buffer (10% hematocrit) over a range of left ventricular afterload (30-100 cmH(2)O) and cardiac outputs (30-180 ml/min). Left ventricular monophasic action potential duration(APD) was significantly shorter at low afterload and high cardiac output in buffer-perfused (114 +/- 35 ms) compared with blood-perfused hearts (177 +/- 23 ms, P < 0.001). APD shortened in blood-perfused hearts after an increase in afterload to 100 cmH(2)O (P < 0.05), and APD was similar in blood-perfused (151 +/- 19 ms) compared with buffer-perfused hearts (142 +/- 24 ms, P = NS). Ventricular effective refractory period (VERP) was significantly shorter at low afterload in buffer-perfused (154 +/- 32 ms) compared with blood-perfused hearts (227 +/- 17 ms, P < 0.001). VERP shortened in blood-perfused hearts after an increase in afterload to 100 cmH(2)O (P < 0.05) and was similar in blood-perfused (166 +/- 26 ms) compared with buffer-perfused hearts (151 +/- 37ms, P = NS). Determination of VERP was associated with induction of ventricular fibrillation in 10 of 15 buffer-perfused hearts, whereas ventricular fibrillation was not observed in blood-perfused hearts (P < 0.001). Thus significant differences in ventricular repolarization andcardiac hemodynamics are observed in working rabbit hearts perfused with a blood-buffer perfusate compared with a crystalloid buffer. Blood-perfused working hearts are electrophysiologically more stable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:22:05