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Titolo:
KINETICS OF THE INHIBITION OF XANTHINE DEHYDROGENASE AND OF THE REVERSIBLE AND IRREVERSIBLE FORMS OF XANTHINE-OXIDASE BY SILIBININ AND BENDAZAC
Autore:
SILVA MP; MIRA L; LIMA J; MANSO CF;
Indirizzi:
FAC MED LISBON,INST QUIM FISIOL,AV PROF EGAS MONIZ P-1600 LISBON PORTUGAL
Titolo Testata:
Environmental toxicology and pharmacology
fascicolo: 4, volume: 1, anno: 1996,
pagine: 279 - 284
SICI:
1382-6689(1996)1:4<279:KOTIOX>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER; ISCHEMIA-REPERFUSION; LIPID-PEROXIDATION; INJURY; PURIFICATION; PREVENTION; CONVERSION; SILYMARIN; MECHANISM; ENZYME;
Keywords:
XANTHINE OXIDASE; XANTHINE DEHYDROGENASE; SILIBININ; BENDAZAC; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Silva et al., "KINETICS OF THE INHIBITION OF XANTHINE DEHYDROGENASE AND OF THE REVERSIBLE AND IRREVERSIBLE FORMS OF XANTHINE-OXIDASE BY SILIBININ AND BENDAZAC", Environmental toxicology and pharmacology, 1(4), 1996, pp. 279-284

Abstract

Xanthine oxidase exists in vivo predominantly as a NAD(+)-dependent dehydrogenase form (xanthine dehydrogenase) which can be transformed into oxygen-dependent oxidase forms as a result of sulfhydryl oxidation (reversible xanthine oxidase) or proteolysis (irreversible xanthine oxidase). Xanthine oxidase has been hypothesized to be a potential source of oxygen-derived free radicals during reperfusion of ischemic tissues. Xanthine dehydrogenase was purified from rat liver and converted into reversible xanthine oxidase by heating at 37 degrees C and into irreversible xanthine oxidase by proteolysis with trypsin. Silibinin andbendazac are compounds used in therapeutics and to which free radicalscavenging properties were ascribed. The effects of the compounds silibinin and bendazac on the different forms of the enzyme were studied. Silibinin inhibited all the forms of the enzyme but bendazac inhibited only reversible and irreversible xanthine oxidase. The inhibitions seem to be mixed non-competitive-competitive. The authors discuss the hypothesis that selective inhibitors of xanthine oxidase, preventing the interruption of uric acid formation, may have some advantage over the inhibitors of both xanthine dehydrogenase and xanthine oxidase in the treatment and prevention of situations such as ischemia and reperfusion syndromes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:15:03