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Titolo:
HUMAN COLONIC MUCOSA POSSESSES A MIXED POPULATION OF 5-HT RECEPTORS
Autore:
BORMAN RA; BURLEIGH DE;
Indirizzi:
UNIV LONDON QUEEN MARY & WESTFIELD COLL,DEPT PHARMACOL,MILE END RD LONDON E1 4NS ENGLAND UNIV LONDON QUEEN MARY & WESTFIELD COLL,DEPT PHARMACOL LONDON E1 4NS ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 309, anno: 1996,
pagine: 271 - 274
SICI:
0014-2999(1996)309:3<271:HCMPAM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTAL COLON; ELECTROLYTE TRANSPORT; 5-HYDROXYTRYPTAMINE; RAT; SECRETION;
Keywords:
5-HT (5-HYDROXYTRYPTAMINE, SEROTONIN); 5-HT RECEPTOR; SECRETION; (HUMAN); COLON; MUCOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Borman e D.E. Burleigh, "HUMAN COLONIC MUCOSA POSSESSES A MIXED POPULATION OF 5-HT RECEPTORS", European journal of pharmacology, 309(3), 1996, pp. 271-274

Abstract

The aim of this study was to characterise the 5-HT receptor(s) mediating secretory responses of isolated human colonic mucosa to 5-HT. Sheets of muscle-stripped mucosa from proximal (ascending) and distal (sigmoid) human colon were set up in Ussing chambers for measurement of short-circuit current (I-SC). Serosal application of 5-HT led to non-neural, concentration-dependent increases in I-SC. Desensitisation to 5-HT was observed with ascending and sigmoid colonic mucosa. Using selective 5-HT antagonists we have shown that 5-HT induces secretion in sigmoid colon via a 5-HT2A receptor. In ascending colon a combination of 5-HT2A and 5-HT4 receptors appears to be involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:42:52