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Titolo:
INTERLEUKIN-2 PRODUCTION IN-VITRO BY PERIPHERAL LYMPHOCYTES IN RESPONSE TO HUMAN PAPILLOMAVIRUS-DERIVED PEPTIDES - CORRELATION WITH CERVICAL PATHOLOGY
Autore:
TSUKUI T; HILDESHEIM A; SCHIFFMAN MH; LUCCI J; CONTOIS D; LAWLER P; RUSH BB; LORINCZ AT; CORRIGAN A; BURK RD; QU WM; MARSHALL MA; MANN D; CARRINGTON M; CLERICI M; SHEARER GM; CARBONE DP; SCOTT DR; HOUGHTEN RA; BERZOFSKY JA;
Indirizzi:
NCI,MOL IMMUNOGENET & VACCINE RES SECT,METAB BRANCH,BLDG 10,ROOM 6B-12 MSC 1578 BETHESDA MD 20892 NCI,MOL IMMUNOGENET & VACCINE RES SECT,METAB BRANCH BETHESDA MD 20892 NCI,ENVIRONM EPIDEMIOL BRANCH BETHESDA MD 20892 NCI,EXPT IMMUNOL BRANCH BETHESDA MD 20892 UNIV TEXAS,SW MED SCH DALLAS TX 75235 KAISER PERMANENTE PORTLAND OR 97227 DIGENE DIAGNOST SILVER SPRING MD 20904 YESHIVA UNIV ALBERT EINSTEIN COLL MED BRONX NY 10461 NCI,FREDERICK CANC RES & DEV CTR,VIRAL CARCINOGENESIS LAB FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,SCI APPLICAT INT CORP,INTRAMURAL RESSUPPORT PROGRAM FREDERICK MD 21702 TORREY PINES INST MOL STUDIES SAN DIEGO CA 92121
Titolo Testata:
Cancer research
fascicolo: 17, volume: 56, anno: 1996,
pagine: 3967 - 3974
SICI:
0008-5472(1996)56:17<3967:IPIBPL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSES; LEISHMANIA-MAJOR; T-CELL; INTRAEPITHELIAL NEOPLASIA; SEROPOSITIVE INDIVIDUALS; TRANSPLANTATION IMMUNITY; SEZARY-SYNDROME; B-LYMPHOCYTES; TH2 SUBSETS; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
T. Tsukui et al., "INTERLEUKIN-2 PRODUCTION IN-VITRO BY PERIPHERAL LYMPHOCYTES IN RESPONSE TO HUMAN PAPILLOMAVIRUS-DERIVED PEPTIDES - CORRELATION WITH CERVICAL PATHOLOGY", Cancer research, 56(17), 1996, pp. 3967-3974

Abstract

Human papillomavirus (HPV) is believed to be the major cause of cervical cancer. To investigate whether a cellular immune response, especially a T helper type 1 response, is related to the natural defense against HPV-related cervical lesions, the interleukin 2 response of peripheral blood lymphocytes in vitro to overlapping peptides from HPV-16 E6and E7 oncoproteins was compared with the degree of cervical cytological abnormality among 140 women in a cross-sectional study. We compared 66 women diagnosed with low-grade squamous intraepithelial lesions (LSIL), 21 with high-grade squamous intraepithelial lesions (HSIL), and28 with invasive cervical cancer with 25 women who were cytologicallynormal but previously HPV-16 DNA positive. The fraction showing strong interleukin 2 production against HPV-16 peptides was greatest among cytologically normal women (35%) and declined with increasing disease severity [LSIL] (20%), HSIL (17%), and cancer patients (7%); chi(2) test P for the trend = 0.02], whereas the responses against a recall influenza antigen were not significantly different among groups. Our finding suggests that a T helper lymphocyte type 1 response to HPV antigens is associated with disease status. This result may reflect a targeted effect of the disease on immune function or a protective effect of the immune response against disease progression.

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Documento generato il 28/01/21 alle ore 07:47:23