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Titolo:
HETEROGENEITY IN SUSCEPTIBILITY TO METRONIDAZOLE AMONG HELICOBACTER-PYLORI ISOLATES FROM PATIENTS WITH GASTRITIS OR PEPTIC-ULCER DISEASE
Autore:
WEEL JFL; VANDERHULST RWM; GERRITS Y; TYTGAT GNJ; VANDERENDE A; DANKERT J;
Indirizzi:
UNIV AMSTERDAM,ACAD MED CTR,DEPT MED MICROBIOL,MEIBERGDREEF 9 NL-1105AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT GASTROENTEROL NL-1105 AZ AMSTERDAM NETHERLANDS
Titolo Testata:
Journal of clinical microbiology
fascicolo: 9, volume: 34, anno: 1996,
pagine: 2158 - 2162
SICI:
0095-1137(1996)34:9<2158:HISTMA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT STAPHYLOCOCCUS-AUREUS; METHICILLIN; STRAINS; MUCOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.F.L. Weel et al., "HETEROGENEITY IN SUSCEPTIBILITY TO METRONIDAZOLE AMONG HELICOBACTER-PYLORI ISOLATES FROM PATIENTS WITH GASTRITIS OR PEPTIC-ULCER DISEASE", Journal of clinical microbiology, 34(9), 1996, pp. 2158-2162

Abstract

Combination therapies that include metronidazole (MTZ) are the most successful therapies used in eradicating Helicobacter pylori, In this study, the prevalence and the relevance of heterogeneity in susceptibility to MTZ among H. pylori populations of 156 patients were evaluated. The results of this study show that 37 patients (24%) were infected with MTZ-resistant H. pylori (MIC greater than or equal to 8 mu g/ml). Furthermore, 33% (52 of 156) of the patients were found to be infectedwith H, pylori populations heterogeneous for their susceptibility to MTZ, The reassessment of the MICs of MTZ for these 52 H, pylori populations revealed MTZ resistance in 28 of them, increasing the number of MTZ-resistant H, py[ori populations among the 156 patients to 65 (42%). Out of 20 isolates, 2 (10%) heterogeneous in their susceptibility toMTZ also appeared to be heterogeneous at the genome level as determined by randomly amplified polymorphic DNA fingerprinting. In conclusion, the results show the limitations and risk of possible misinterpretations when only a single colony, picked from the primary H, pylori populations isolated from patients, is analyzed for its susceptibility to MTZ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:20:18