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Titolo:
BENEFICIAL EFFECT OF A NOVEL PENTADECAPEPTIDE BPC-157 ON GASTRIC-LESIONS INDUCED BY RESTRAINT STRESS, ETHANOL, INDOMETHACIN, AND CAPSAICIN NEUROTOXICITY
Autore:
SIKIRIC P; SEIWERTH S; GRABAREVIC Z; RUCMAN R; PETEK M; JAGIC V; TURKOVIC B; ROTKVIC I; MISE S; ZORICIC I; GJURASIN M; KONJEVODA P; SEPAROVIC J; LJUBANOVIC D; ARTUKOVIC B; BRATULIC M; TISLJAR M; BULJAT G; MIKLIC P; MAROVIC A;
Indirizzi:
UNIV ZAGREB,FAC MED,DEPT PHARMACOL,SALATA 11,POB 916 HR-10000 ZAGREB CROATIA UNIV ZAGREB,MED & VET FAC,CTR DIGEST DIS ZAGREB 41000 CROATIA
Titolo Testata:
Digestive diseases and sciences
fascicolo: 8, volume: 41, anno: 1996,
pagine: 1604 - 1614
SICI:
0163-2116(1996)41:8<1604:BEOANP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; PRIMARY SENSORY NEURONS; DOPAMINE AGONISTS; NITRIC-OXIDE; RAT; ANTAGONISTS; MECHANISMS; STOMACH; CYTOPROTECTION; NEUROPEPTIDES;
Keywords:
PENTADECAPEPTIDE; BPC 157; ORGANOPROTECTIVE PEPTIDE; GASTRIC LESIONS; CAPSAICIN NEUROTOXICITY; RATS; GASTROPROTECTION; NEUROPROTECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
P. Sikiric et al., "BENEFICIAL EFFECT OF A NOVEL PENTADECAPEPTIDE BPC-157 ON GASTRIC-LESIONS INDUCED BY RESTRAINT STRESS, ETHANOL, INDOMETHACIN, AND CAPSAICIN NEUROTOXICITY", Digestive diseases and sciences, 41(8), 1996, pp. 1604-1614

Abstract

Very recently, the integrity of capsaicin somatosensory neurons and their protection were suggested to be related to the activity in nociception of a newly discovered 15-amino acid peptide, BPC 157, shown to have strong beneficial effect on intestinal and liver lesions. Therefore, from this viewpoint, we have studied the gastroprotective effect ofthe pentade-capeptide BPC 157, on gastric lesions produced in rats by96% ethanol, restraint stress, and indomethacin. The possible involvement of sensory neurons in the salutary actions of BPC 157 (10 mu g/kg, 10 ng/kg intraperitoneally) was studied with capsaicin, which has differential effects on sensory neurons: a high dose in adult (125 mg/kgsubcutaneously, 3 months old) or administration (50 mg/kg subcutaneously) to neonatal animals (age of the 7 days) destroys sensory fibers, whereas a low dose (500 mu g/kg intraperitoneally) activates neurotransmitter release and protective effects on the mucosa. In the absence of capsaicin, BPC 157 protected gastric mucosa against ethanol, restraint, and indomethacin application. In the presence of neurotoxic doses of capsaicin, the negative influence of capsaicin on restraint, ethanol, or indomethacin lesions consistently affected salutary activity of BPC 157 was applied as a single nanogram-regimen, but the mucosal protection was fully reversed when the same dose was used daily. In line with the excitatory dose of capsaicin the beneficial effectiveness of BPC 157 appears to be increased as well. Taken together, these data provide evidence for complex synergistic interaction between the beneficial effectiveness of BPC 157 and peptidergic sensory afferent neuron activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:43:17