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Titolo:
CORRELATED CHANGES IN SYMPTOMS AND NEUROTRANSMITTER INDEXES DURING MAINTENANCE TREATMENT WITH CLOZAPINE OR CONVENTIONAL NEUROLEPTICS IN ADOLESCENTS AND YOUNG-ADULTS WITH SCHIZOPHRENIA
Autore:
SCHULZ E; FLEISCHHAKER C; REMSCHMIDT HE;
Indirizzi:
UNIV MARBURG,DEPT CHILD & ADOLESCENT PSYCHIAT,HANS SACHS STR 6 D-35033 MARBURG GERMANY
Titolo Testata:
Journal of child and adolescent psychopharmacology
fascicolo: 2, volume: 6, anno: 1996,
pagine: 119 - 131
SICI:
1044-5463(1996)6:2<119:CCISAN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN PLASMA; ULTRAVIOLET DETECTION; N-DESMETHYLCLOZAPINE; ONSET SCHIZOPHRENIA; NEGATIVE SYMPTOMS; CLINICAL EFFICACY; OPEN TRIAL; METABOLITES; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
E. Schulz et al., "CORRELATED CHANGES IN SYMPTOMS AND NEUROTRANSMITTER INDEXES DURING MAINTENANCE TREATMENT WITH CLOZAPINE OR CONVENTIONAL NEUROLEPTICS IN ADOLESCENTS AND YOUNG-ADULTS WITH SCHIZOPHRENIA", Journal of child and adolescent psychopharmacology, 6(2), 1996, pp. 119-131

Abstract

A study of 40 young patients (age 14-22 years) with DSM-III-R schizophrenia (without substance abuse) was conducted following a mean of 3.4years of neuroleptic treatment. After failing on conventional agents in clinical trials lasting a mean of 2 years, 20 patients were prospectively maintained on open-label clozapine (mean 324 mg daily), and another 20 patients continued on typical neuroleptics (mean 465 mg chlorpromazine-equivalents daily). Patients were then sampled for biochemical measures and assessed for psychopathology (Brief Psychiatric Rating Scale, Scales for the Assessment of Positive/Negative Symptoms) on sixoccasions at consecutive 6-week intervals during maintenance treatment on clozapine or conventional neuroleptics. There were 22-fold interindividual differences in clozapine levels and also high intraindividual differences over time. Maintenance dosage was linearly related to plasma levels of clozapine and its metabolites, Prolactin levels were elevated with typical neuroleptics but not clozapine. Blood levels of serotonin, methoxyhydroxyphenylglycol (MHPG), norepinephrine, and epinephrine (but not dopamine) were significantly higher in clozapine-treated patients than in conventionally treated patients, Higher serotonin Levels were associated with significantly fewer negative symptoms, whereas higher MHPG levels were correlated with less depression. These findings suggest involvement of norepinephrine and serotonin in the pathophysiology of schizophrenia (with depression associated with lower MHPG levels and negative symptoms associated with lower serotonin levels)and in the therapeutic actions of clozapine. Speculatively, a treatment strategy of targeting specific neurotransmitter systems might be based on the presence of specific symptoms in adolescents and young adults with schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:00:30