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Titolo:
CEREBROSPINAL-FLUID CONCENTRATIONS OF CORTICOTROPIN-RELEASING HORMONE(CRH) AND DIAZEPAM-BINDING INHIBITOR (DBI) DURING ALCOHOL-WITHDRAWAL AND ABSTINENCE
Autore:
ADINOFF B; ANTON R; LINNOILA M; GUIDOTTI A; NEMEROFF CB; BISSETTE G;
Indirizzi:
VET ADM MED CTR,116A,4500 S LANCASTER RD DALLAS TX 75216 UNIV TEXAS,SW MED CTR,DEPT PSYCHIAT DALLAS TX 00000 MED UNIV S CAROLINA,DEPT PSYCHIAT CHARLESTON SC 29425 NIAAA,DICBR,CLIN STUDIES LAB BETHESDA MD 20892 NATHAN S KLINE INST PSYCHIAT RES,CTR NEUROPHARMACOL ORANGEBURG NY 10962 EMORY UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI ATLANTA GA 00000 UNIV MISSISSIPPI,DEPT PSYCHIAT JACKSON MS 39216
Titolo Testata:
Neuropsychopharmacology
fascicolo: 3, volume: 15, anno: 1996,
pagine: 288 - 295
SICI:
0893-133X(1996)15:3<288:CCOCH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; FACTOR-LIKE IMMUNOREACTIVITY; ETHANOL WITHDRAWAL; BENZODIAZEPINE ANTAGONIST; DEPRESSED-PATIENTS; FACTOR RECEPTORS; RAT; REVERSES; ANXIETY; BRAIN;
Keywords:
ALCOHOL WITHDRAWAL; ALCOHOLISM; DIAZEPAM BINDING INHIBITOR; CORTICOTROPIN RELEASING HORMONE; GABA RECEPTOR; HPA AXIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
B. Adinoff et al., "CEREBROSPINAL-FLUID CONCENTRATIONS OF CORTICOTROPIN-RELEASING HORMONE(CRH) AND DIAZEPAM-BINDING INHIBITOR (DBI) DURING ALCOHOL-WITHDRAWAL AND ABSTINENCE", Neuropsychopharmacology, 15(3), 1996, pp. 288-295

Abstract

The neuropeptides diazepam binding inhibitor (DBI) and corticotropin-releasing hormone (CRH) elicit anxietylike symptoms when administered intracerebroventricularly to laboratory animals. Because of the similarities between the symptoms of certain anxiety states and the alcohol withdrawal syndrome, we hypothesized that increased secretion of either of these endogenous neuropeptides may, at least in part, be responsible for the symptoms of alcohol withdrawal. We therefore measured DBI and CRH concentrations in cerebrospinal fluid (CSF) of 15 alcohol-dependent patients during acute withdrawal (Day 1) and again at 3 week's abstinence (Day 21). In addition, plasma concentrations of cortisol were measured to evaluate the relationship between pituitary-adrenal axisactivation and CSF CRH concentrations. CSF CRH (p < .04), but not CSFDBI, was significantly higher on Day 1 than on Day 21. Although therewas a significant decrease in plasma cortisol from Day 1 to Day 21 (p< .001), a significant correlation between CSF CRH and plasma cortisol concentrations was not observed at either time point. Neither CSF neuropeptide correlated with clinical measures of withdrawal severity. These tentative findings may implicate CRH, but not DBI, in the pathogenesis of alcohol withdrawal. Alternately, the central release of CRH and DBI may not be adequately reflected in lumbar CSF.

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Documento generato il 02/04/20 alle ore 22:19:07