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Titolo:
BREATHING AND BRAIN BLOOD-FLOW DURING SLEEP IN PATIENTS WITH CHRONIC MOUNTAIN-SICKNESS
Autore:
SUN SF; OLIVERPICKETT C; PING Y; MICCO AJ; DROMA T; ZAMUDIO S; ZHUANG JG; HUANG SY; MCCULLOUGH RG; CYMERMAN A; MOORE LG;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR B133,CARDIOVASC PULM RES LAB,4200 E 9TH AVE DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR B133,CARDIOVASC PULM RES LAB DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT ANESTHESIOL DENVER CO 80262 UNIV COLORADO,DEPT ANTHROPOL DENVER CO 80217 USA,MED RES & DEV COMMAND,ALTITUDE PHYSIOL & MED DIV NATICK MA 01760 TIBET INST MED SCI LHASA 85000 TIBET PEOPLES R CHINA
Titolo Testata:
Journal of applied physiology
fascicolo: 2, volume: 81, anno: 1996,
pagine: 611 - 618
SICI:
8750-7587(1996)81:2<611:BABBDS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYE-MOVEMENT SLEEP; HIGH-ALTITUDE; EXCESSIVE POLYCYTHEMIA; CEREBRAL HEMODYNAMICS; VELOCITY; APNEA; RESPIRATION; RESIDENTS; HYPOPNEA;
Keywords:
TIBET; SLEEP-DISORDERED BREATHING; ARTERIAL OXYGEN SATURATION; DOPPLER FLOW VELOCITY; HIGH ALTITUDE; HYPOXIA; CHINA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S.F. Sun et al., "BREATHING AND BRAIN BLOOD-FLOW DURING SLEEP IN PATIENTS WITH CHRONIC MOUNTAIN-SICKNESS", Journal of applied physiology, 81(2), 1996, pp. 611-618

Abstract

Chronic mountain sickness (CMS) patients have lower arterial O-2 saturation (Sa(O2)) during sleep compared with healthy high-altitude residents, but whether nocturnal arterial Oa content (Ca-O2) and brain O-2 delivery are reduced is unknown. We measured Sa(O2), Ca-O2, sleep-disordered breathing (SDB), and internal carotid artery flow velocity in 8CMS patients, 8 age-matched healthy CMS controls, 11 healthy younger-aged Han, and 11 healthy younger-aged Tibetan male residents of Lhasa,Tibet (3,658 m). CMS patients spent a greater portion of the night inSDB (total no. of episodes of apnea, hypopnea, and hypoventilation) than did the CMS controls, young Han, or young Tibetans (15% vs. 5, 1, and 1%, respectively; P < 0.05) because of more frequent apnea and hypoventilation episodes and longer duration of all types of episodes. SDB and unexplained arterial O-2 desaturation caused nocturnal Sa(O2) tobe lower and more variable in CMS patients than in CMS controls or inyounger-aged Han or Tibetan men. Average Ca-O2 was similar, but the CMS patients spent 29%, whereas the other groups spent <4%, of the night at values <18 ml O-2/100 ml whole blood. Internal carotid artery flow velocity during wakefulness was similar in CMS patients and CMS controls despite higher end-tidal Pco(2) values in the CMS patients. When contiguous sleep stages are compared, flow velocity rose from stage 2 to rapid-eye-movement sleep in both groups. Whereas flow velocity remained elevated from awake to rapid-eye-movement sleep in the CMS controls, it fell in the CMS patients. During episodes of SDB, internal carotid flow velocity increased in CMS controls but did not change in the CMS patients such that values were lower in the CMS patients than in CMS controls at the end and after SDB episodes. We concluded that SDB and episodes of unexplained desaturation lowered nocturnal Sa(O2) and Ca-O2, which, together with a lack of compensatory increase in internalcarotid artery flow velocity, likely decreased brain O-2 delivery in CMS patients during a considerable portion of the night.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 08:04:54