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Titolo:
INTERACTIONS AMONG METABOLIC-RATE, HYPOXIA, AND CONTROL OF BREATHING
Autore:
GAUTIER H;
Indirizzi:
UNIV PARIS 06,ATELIER PHYSIOL RESP,27 RUE CHALIGNY F-75012 PARIS FRANCE
Titolo Testata:
Journal of applied physiology
fascicolo: 2, volume: 81, anno: 1996,
pagine: 521 - 527
SICI:
8750-7587(1996)81:2<521:IAMHAC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTREME SIMULATED ALTITUDE; BODY-TEMPERATURE; CAROTID-BODY; AWAKE RATS; VENTILATORY RESPONSES; CONSCIOUS RATS; BEHAVIORAL THERMOREGULATION; AMBIENT-TEMPERATURE; OPERATION EVEREST; DENERVATED RATS;
Keywords:
HYPOXIC HYPOMETABOLISM; HYPOTHALAMUS; THERMOREGULATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
H. Gautier, "INTERACTIONS AMONG METABOLIC-RATE, HYPOXIA, AND CONTROL OF BREATHING", Journal of applied physiology, 81(2), 1996, pp. 521-527

Abstract

This review attempts to emphasize the fact that the interpretation ofthe ventilatory response to hypoxia may be complicated by the reduction in metabolic rate that is often associated with hypoxia. The hypoxic hypometabolism is more apparent when oxygen consumption is relatively high, either in small or young mammals at subnormal ambient temperatures or in larger mammals exposed to cold. This hypometabolism is not mediated by an activation of the arterial chemoreceptors and, furthermore, may result from a decrease in arterial oxygen content independentof the arterial Po-2. Substantial experimental evidence supports the hypothesis of a lowering of the thermoregulatory set point during hypoxia through a direct action on central neural structures. The ventilatory response to hypoxia, which may appear blunted or depressed, especially in small animals exposed to cold, should in fact be reevaluated by taking into account the hypometabolism and hypothermia associated with hypoxia. Finally, it is emphasized that the mechanisms involved in control of body temperature and those that account for the interactions with hypoxia are located in the hypothalamus. This suggests that common integrative structures are probably involved in the metabolic and ventilatory responses to hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:29:00