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Titolo:
2 SYNAPTOTAGMIN GENES, SYT1 AND SYT4, ARE DIFFERENTIALLY REGULATED INADULT BRAIN AND DURING POSTNATAL-DEVELOPMENT FOLLOWING KAINIC ACID-INDUCED SEIZURES
Autore:
TOCCO G; BI XN; VICIAN L; LIM IK; HERSCHMAN H; BAUDRY M;
Indirizzi:
UNIV SO CALIF,NEUROSCI PROGRAM,HEDCO NEUROSCI BLDG LOS ANGELES CA 90089 UNIV CALIF LOS ANGELES,CTR HLTH SCI,DEPT BIOL CHEM LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,CTR HLTH SCI,LAB STRUCT BIOL & MOL LOS ANGELESCA 90024
Titolo Testata:
Molecular brain research
fascicolo: 2, volume: 40, anno: 1996,
pagine: 229 - 239
SICI:
0169-328X(1996)40:2<229:2SGSAS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; DAMAGE SYNDROME; MESSENGER-RNA; EXPRESSION; HIPPOCAMPUS; MATURATION; BINDING; SYSTEM; CELLS; DEATH;
Keywords:
KAINIC ACID; SYNAPTOTAGMIN; DEVELOPMENT; SEIZURE; HIPPOCAMPUS; LIMBIC SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G. Tocco et al., "2 SYNAPTOTAGMIN GENES, SYT1 AND SYT4, ARE DIFFERENTIALLY REGULATED INADULT BRAIN AND DURING POSTNATAL-DEVELOPMENT FOLLOWING KAINIC ACID-INDUCED SEIZURES", Molecular brain research, 40(2), 1996, pp. 229-239

Abstract

The synaptotagmins together with other vesicle proteins are thought to be essential for the docking and/or fusion of synaptic vesicles withthe plasma membrane that occurs following depolarization and calcium influx in presynatic terminals. Syt4, the fourth identified member of the synaptotagmin family, is inducible in PC12 cells by depolarizationand secretagogues, and in Limbic regions of the adult rat brain by kainic acid-induced seizures. In the present study, we examined the timecourse of the seizure-induced changes in the expression of Syt4 and Syt1, both in adult animals and during the postnatal period. Syt4 was transiently induced in several structures of the adult rat brain following seizure activity with peak inductions between 4 and 8 h and overalreturn to control values by 30 h. No induction was observed followingseizure activity in 7-day-old animals. The brain regions most sensitive to increased induction were, in decreasing order of sensitivity, hippocampal pyramidal cells, dentate granule cells and piriform cortex pyramidal cells, The brain areas showing the greatest Syt4 stimulation in adults were also the areas in which Syt4 was induced by seizures earlier in development. In contrast, Syt1 mRNA was depressed in adult brains following seizure activity, particularly in the dentate granule cells. Our results suggest that the differential regulation of different synaptotagmin genes following excessive neuronal activity might participate in rapid adaptation of subsequent transmitter release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 10:19:33