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Titolo:
CLONING AND CHARACTERIZATION OF A BIFUNCTIONAL METABOTROPIC RECEPTOR-ACTIVATED BY BOTH EXTRACELLULAR CALCIUM AND GLUTAMATE
Autore:
KUBOKAWA K; MIYASHITA T; NAGASAWA H; KUBO Y;
Indirizzi:
TOKYO METROPOLITAN INST NEUROSCI,DEPT NEUROPHYSIOL,MUSASHIDAI 2-6 FUCHU TOKYO 183 JAPAN TOKYO METROPOLITAN INST NEUROSCI,DEPT NEUROPHYSIOL FUCHU TOKYO 183 JAPAN UNIV TOKYO,OCEAN RES INST,LAB MOLEC BIOL MARINE ORGANISMS,NAKANO KU TOKYO 164 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 392, anno: 1996,
pagine: 71 - 76
SICI:
0014-5793(1996)392:1<71:CACOAB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; MGLUR1 MUTANT MICE; MOLECULAR CHARACTERIZATION; FUNCTIONAL EXPRESSION; SIGNAL-TRANSDUCTION; SEQUENCE ALIGNMENT; SENSING RECEPTOR; XENOPUS OOCYTES; RAT;
Keywords:
BIFUNCTIONAL; METABOTROPIC; RECEPTOR; CALCIUM; GLUTAMATE; CDNA; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K. Kubokawa et al., "CLONING AND CHARACTERIZATION OF A BIFUNCTIONAL METABOTROPIC RECEPTOR-ACTIVATED BY BOTH EXTRACELLULAR CALCIUM AND GLUTAMATE", FEBS letters, 392(1), 1996, pp. 71-76

Abstract

A cDNA from salmon brain which induces a consistent activation of Ca2 dependent Cl- (Ca2+-Cl-) current in Xenopus oocytes in the saline solution was isolated by an expression cloning method, The primary structure showed a high homology with the metabotropic glutamate receptors (mGluR), and a limited homology with the Ca2+/polyvalent cation receptors (CaR), The encoded protein was functionally characterized for the sensitivity to extracellular Ca2+ (Ca-0(2+)), and the consistent activation of Ca2+-Cl- current was determined to be due to Ca2+ contained in the saline solution, It was also confirmed that the encoded protein has a function to sense glutamate. An increase in inositol 1,4,5-triphosphate turnover was observed when either Ca2+ or glutamate was applied. Thus, the encoded protein was identified as a bifunctional metabotropic receptor for both Ca2+ and glutamate, In addition, rat mGluR1 alpha was also shown to be activated by Ca-0(2+). This is the first report of a G-protein coupled receptor which is activated by two totally different physiological agonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:46:46