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Titolo:
CROSSED PROJECTION NEURONS ARE GENERATED PRIOR TO UNCROSSED PROJECTION NEURONS IN THE LATERAL SUPERIOR OLIVE OF THE RAT
Autore:
KUDO M; KITAO Y; OKOYAMA S; MORIYA M; KAWANO J;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT ANAT,TAKARA MACHI 13-1 KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Developmental brain research
fascicolo: 1, volume: 95, anno: 1996,
pagine: 72 - 78
SICI:
0165-3806(1996)95:1<72:CPNAGP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR COLLICULUS; ACOUSTIC CHIASM; NEUROGENESIS; GLYCINE; PATHWAY; NUCLEUS; FERRET; CELLS;
Keywords:
AUDITORY PATHWAY; SUPERIOR OLIVARY COMPLEX; FLUOROGOLD; DEVELOPMENT; LATERALITY OF PROJECTION; THYMIDINE ANALOG; NEUROGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M. Kudo et al., "CROSSED PROJECTION NEURONS ARE GENERATED PRIOR TO UNCROSSED PROJECTION NEURONS IN THE LATERAL SUPERIOR OLIVE OF THE RAT", Developmental brain research, 95(1), 1996, pp. 72-78

Abstract

The present study examined in the lateral superior olive (LSO) of therat whether LSO neurons projecting to the ipsilateral inferior colliculus (IC) might be generated later than those projecting to the contralateral IC. Rat fetuses were exposed in utero to 5-bromodeoxyuridine (BrdU), a thymidine analogue, to label neurons proliferating at different embryonic stages from day Ell through to E20. Upon reaching adulthood, the rats were given unilateral injections of fluoro-gold (FG), a retrograde fluorescent tracer, into the IC. Subsequently, the tissue sections of the brains obtained from the rats were immunostained for BrdU to simultaneously detect neurons that were BrdU-positive and/or FG-positive. BrdU-positive LSO neurons were found in the rats which had been exposed to BrdU during E12-E16. In E12 and E13 BrdU-exposure cases,the vast majority of double-labeled (BrdU-positive and FG-positive) neurons were seen on the contralateral side to the FG injection. In E14, E15 and E16 BrdU-exposure cases, in contrast, all double-labeled neurons were found on the ipsilateral side to the FG injection. The distribution of these double-labeled neurons within the nucleus was diffusein all the BrdU-exposure cases. Thus, the results indicate that LSO neurons are generated during E12-E16, that the crossed projection neurons are generated 1-4 days earlier than the uncrossed projection neurons, and that no topographical relationships exist between the early- and the late-generated populations of the LSO neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:33:20