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Titolo:
COMBINATORIAL EFFECTS OF MONOCLONAL ANTI-P120 ANTIBODY (MABP120), LIPOSOMES AND HYPERTHERMIA ON MCF-7 AND LOX TUMOR-CELL LINES
Autore:
PERLAKY L; BUSCH RK; BUSCH H;
Indirizzi:
BAYLOR COLL MED,DEPT PHARMACOL,1 BAYLOR PLAZA HOUSTON TX 77030 BAYLOR COLL MED,DEPT PHARMACOL HOUSTON TX 77030
Titolo Testata:
Oncology research
fascicolo: 9, volume: 8, anno: 1996,
pagine: 363 - 369
SICI:
0965-0407(1996)8:9<363:CEOMAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOLAR ANTIGEN P120; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE ISIS-3466; EX-VIVO EXPRESSION; BREAST-CANCER; IN-VITRO; NIH/3T3 CELLS; PROTEIN P120; PROLIFERATION; IDENTIFICATION; CONSTRUCT;
Keywords:
MONOCLONAL ANTIBODY; P120; LIPOSOME; HYPERTHERMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
L. Perlaky et al., "COMBINATORIAL EFFECTS OF MONOCLONAL ANTI-P120 ANTIBODY (MABP120), LIPOSOMES AND HYPERTHERMIA ON MCF-7 AND LOX TUMOR-CELL LINES", Oncology research, 8(9), 1996, pp. 363-369

Abstract

The human nucleolar protein p120 is highly expressed in human cancers. Its high expression in breast cancer correlates with a poor prognosis, and its overexpression in 3T3 mouse fibroblasts causes malignant transformation. This study reports that a combination of monoclonal anti-p120 antibody (MAbp120), liposomes (Lipo), and hyperthermia (HT) resulted in enhanced antitumor effects in cultured human breast adenocarcinoma (MCF-7) and human amelanotic melanoma (LOX) cells. Monoclonal antibody uptake and intracellular localization of the protein p120 were monitored by double labeling indirect immunofluorescence. Cell growth inhibition by the combination of MAbp120+Lipo+HT was 65% for MCF-7 cells and 96% for LOX cells. When tested on LOX cells, monoclonal antibodies (MAbB23, MAbC23) to other nucleolar proteins (B23, C23) produced only slight cytotoxicity with similar treatment protocols. Copyright (C)1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:37:38