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Titolo:
EXPRESSION OF N-CADHERIN BY HUMAN SQUAMOUS CARCINOMA-CELLS INDUCES A SCATTERED FIBROBLASTIC PHENOTYPE WITH DISRUPTED CELL-CELL ADHESION
Autore:
ISLAM S; CAREY TE; WOLF GT; WHEELOCK MJ; JOHNSON KR;
Indirizzi:
UNIV TOLEDO,DEPT BIOL TOLEDO OH 43606 UNIV TOLEDO,DEPT BIOL TOLEDO OH 43606 UNIV MICHIGAN,DEPT VET AFFAIRS MED CTR,DEPT OTOLARYNGOL ANN ARBOR MI 48109
Titolo Testata:
The Journal of cell biology
fascicolo: 6, volume: 135, anno: 1996,
parte:, 1
pagine: 1643 - 1654
SICI:
0021-9525(1996)135:6<1643:EONBHS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULE E-CADHERIN; ALPHA-CATENIN; BETA-CATENIN; EPITHELIAL-CELLS; CYTOPLASMIC DOMAIN; PROSTATE-CANCER; PLAKOGLOBIN; PROTEIN; GENE; UVOMORULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
S. Islam et al., "EXPRESSION OF N-CADHERIN BY HUMAN SQUAMOUS CARCINOMA-CELLS INDUCES A SCATTERED FIBROBLASTIC PHENOTYPE WITH DISRUPTED CELL-CELL ADHESION", The Journal of cell biology, 135(6), 1996, pp. 1643-1654

Abstract

E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent, homotypic cell-cell adhesion and plays an important role in maintaining the normal phenotype of epithelial cells, Disruption of E-cadherin activity in epithelial cells correlates with formation of metastatic tumors, Decreased adhesive function may be implemented in a number of ways including: (a) decreased expression of E-cadherin; (b) mutations in the gene encoding E-cadherin; or (c) mutations in the genes that encode the catenins, proteins that link the cadherins to the cytoskeleton and are essential for cadherin mediated cell-cell adhesion. In this study, we explored the possibility that inappropriate expression of a nonepithelial cadherin by an epithelial cell might also result indisruption of cell-cell adhesion, We showed that a squamous cell carcinoma-derived cell line expressed N-cadherin and displayed a scatteredfibroblastic phenotype along with decreased expression of E- and P-cadherin. Transfection of this cell line with antisense N-cadherin resulted in reversion to a normal-appearing squamous epithelial cell with increased E- and P-cadherin expression, In addition, transfection of a normal-appearing squamous epithelial cell line with N-cadherin resulted in downregulation of both E- and P-cadherin and a scattered fibroblastic phenotype. In all cases, the levels of expression of N-cadherin and E-cadherin were inversely related to one another, In addition, we showed that some squamous cell carcinomas expressed N-cadherin in situ and those tumors expressing N-cadherin were invasive, These studies led us to propose a novel mechanism for tumorigenesis in squamous epithelial cells; i.e., inadvertent expression of a nonepithelial cadherin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 15:38:18