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Titolo:
HISTOLOGIC-CHANGES AND WOUND-HEALING RESPONSE FOLLOWING 10-PULSE NONCONTACT HOLMIUM - YAG LASER THERMAL KERATOPLASTY
Autore:
KOCH DD; KOHNEN T; ANDERSON JA; BINDER PS; MOORE MN; MENEFEE RF; VALDERAMMA GL; BERRY MJ;
Indirizzi:
BAYLOR COLL MED,CULLEN EYE INST,DEPT OPHTHALMOL,6501 FANNIN,NC200 HOUSTON TX 77030 NATL VIS RES INST,OPHTHALMOL RES LAB SAN DIEGO CA 00000 SUNRISE TECHNOL INC FREMONT CA 00000
Titolo Testata:
Journal of refractive surgery
fascicolo: 5, volume: 12, anno: 1996,
pagine: 623 - 634
SICI:
1081-597X(1996)12:5<623:HAWRF1>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOHISTOCHEMICAL EVALUATION; HUMAN CORNEAS; RABBIT; KERATECTOMY; COLLAGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D.D. Koch et al., "HISTOLOGIC-CHANGES AND WOUND-HEALING RESPONSE FOLLOWING 10-PULSE NONCONTACT HOLMIUM - YAG LASER THERMAL KERATOPLASTY", Journal of refractive surgery, 12(5), 1996, pp. 623-634

Abstract

BACKGROUND: Noncontact holnium:YAG laser thermal keratoplasty (I-Io:YAG LTK) is a promising new technology for correction of hyperopia and astigmatism. We studied the acute histologic changes and wound healingresponse following Ho:YAG LTK performed with treatment parameters encompassing those used in clinical studies. METHODS: We performed 10-pulse noncontact Ho:YAG LTK on three human corneas 1 day before their removal at penetrating keratoplasty and on six New Zealand white rabbit corneas followed for up to 3 months. Tissues were studied with light and transmission electron microscopy and immunohistochemistry. RESULTS: The amount of acute tissue injury increased according to the pulse radiant energy. In human corneas, changes in the irradiated zones included epithelial cell injury and death, loss of fine filamentous structurein Bowman's layer, disruption of stromal lamellae, and keratocyte injury and death. In the rabbit corneas, similar acute changes were noted. By 3 weeks, epithelial hyperplasia and stromal contraction were present. Wound healing in the rabbits included repair of the epithelial attachment complex, keratocyte activation, synthesis of type I collagen,partial restoration of stromal keratan sulfate and type VI collagen, and retrocorneal membrane formation. CONCLUSIONS: Noncontact Ho:YAG LTK produces acute epithelial and stromal tissue changes and in rabbit corneas stimulates a brisk wound healing response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:41:53