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Titolo:
THE 5-HT1B RECEPTOR AGONIST CP-94,253 REDUCES FOOD-INTAKE AND PRESERVES THE BEHAVIORAL SATIETY SEQUENCE
Autore:
HALFORD JCG; BLUNDELL JE;
Indirizzi:
UNIV LEEDS,BIOPSYCHOL GRP LEEDS LS2 9JT W YORKSHIRE ENGLAND
Titolo Testata:
Physiology & behavior
fascicolo: 3, volume: 60, anno: 1996,
pagine: 933 - 939
SICI:
0031-9384(1996)60:3<933:T5RACR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS;
Keywords:
CP-94,253; RU-24969; 5-HT1B; BEHAVIORAL SATIETY SEQUENCE; SATIETY; FOOD INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.C.G. Halford e J.E. Blundell, "THE 5-HT1B RECEPTOR AGONIST CP-94,253 REDUCES FOOD-INTAKE AND PRESERVES THE BEHAVIORAL SATIETY SEQUENCE", Physiology & behavior, 60(3), 1996, pp. 933-939

Abstract

The 5-HT1B receptor has been proposed as a link in the relationship between serotonin and satiety. However, the anorexia induced by RU-24969, a 5-HT1A/1B agonist, has been shown to delay behaviours associated with the onset of satiety, increase the frequency of intake and increase some nonfeeding activities. CP-94,253 is a highly selective agonistat the 5-HT1B receptor site with less affinity for other receptor sites, and has been used in this study to determine if agonism of 5-HT1B receptor sites adjust the behavioural satiety sequence in a way consistent with satiety. The effects of an ED(50) of dose of CP-94,253 (5.0 mg/kg, IP) on eating behaviour of the fasted rat were monitored. Temporal profiles of behaviour duration and frequency were generated. Food intake was reduced 57% by CP-94,253 (p < 0.005). Analysis confirmed that CP-94,253 reduced rearing (p < 0.05) and increased resting (p < 0.05) bur preserved the overall pattern of the satiety sequence. Increased locomotion was not significant and caused no gross disruption of thebehavioural repertoire. Such changes are also produced by prefeeding. In a second experiment, RU-24969 (1.0 mg/kg, IF) reduced food intake by only 30% (p < 0.05) However, RU-24969 markedly disrupted the satiety sequence profile, which did not resemble the profile produced by prefeeding. RU-24969 presumably induces this disruption via a mechanism other than 5-HT1B activation. The use of CP-95,253 demonstrates that selective activation of 5-HT1B receptor sites is sufficient to reduce food intake and enhance satiety as represented by the behavioural satiety sequence.

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Documento generato il 30/11/20 alle ore 05:36:24