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Titolo:
PERIPHERAL ADMINISTRATION OF A CORTICOTROPIN-RELEASING FACTOR ANTAGONIST INCREASES THE VOCALIZING AND LOCOMOTOR-ACTIVITY OF ISOLATED GUINEA-PIG PUPS
Autore:
MCINTURF SM; HENNESSY MB;
Indirizzi:
WRIGHT STATE UNIV,DEPT PSYCHOL DAYTON OH 45435 WRIGHT STATE UNIV,DEPT PSYCHOL DAYTON OH 45435
Titolo Testata:
Physiology & behavior
fascicolo: 3, volume: 60, anno: 1996,
pagine: 707 - 710
SICI:
0031-9384(1996)60:3<707:PAOACF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NERVOUS-SYSTEM; ALPHA-HELICAL CRF; FACTOR RECEPTORS; RATS; HORMONE;
Keywords:
CRF; ISOLATION; MATERNAL SEPARATION; GUINEA PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Mcinturf e M.B. Hennessy, "PERIPHERAL ADMINISTRATION OF A CORTICOTROPIN-RELEASING FACTOR ANTAGONIST INCREASES THE VOCALIZING AND LOCOMOTOR-ACTIVITY OF ISOLATED GUINEA-PIG PUPS", Physiology & behavior, 60(3), 1996, pp. 707-710

Abstract

Guinea pig pups vocalized more and were more active during a 60-min period of isolation in a novel environment when injected SC with 50 mu g of the corticotropin-releasing factor (CRF) antagonist, [D-Phe]CRF(12-41), than when injected with saline vehicle only. More pups exhibited eye closing and extensive piloerection when injected with saline than when injected with the antagonist. Plasma levels of cortisol following testing were not affected by the injections. These results support the hypothesis that endogenous CRF contributes to the normal decline in vocalizing and locomotor activity that guinea pig pups show with continued isolation. The results also suggest that endogenous CRF plays arole in the eye closing and piloerection of isolated pups. The finding that the dose of the antagonist used altered behavior, yet was not sufficient to lower plasma cortisol levels, supports earlier evidence that the observed effects of CRF are not due to the actions of ACTH or glucocorticoids.

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Documento generato il 19/01/20 alle ore 06:12:20