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Titolo:
CONTRACTILE AND CYTOSKELETAL PROTEINS IN URINARY-BLADDER SMOOTH-MUSCLE FROM RATS TREATED WITH EPIDERMAL GROWTH-FACTOR
Autore:
VINTERJENSEN L; UVELIUS B; NEXO E; ARNER A;
Indirizzi:
KH AARHUS UNIV HOSP,DEPT CLIN BIOCHEM,NORREBROGADE 44 DK-8000 AARHUS C DENMARK AALBORG HOSP,DEPT PATHOL DK-9000 AALBORG DENMARK AARHUS UNIV,INST EXPT CLIN RES AARHUS DENMARK UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN LUND UNIV,DEPT PHYSIOL & NEUROSCI LUND SWEDEN
Titolo Testata:
Urological research
fascicolo: 4, volume: 24, anno: 1996,
pagine: 229 - 234
SICI:
0300-5623(1996)24:4<229:CACPIU>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTROPHY; RECEPTOR; REVERSAL; MITOGEN; KIDNEY; CELLS;
Keywords:
ACTIN; DESMIN; GROWTH FACTORS; MYOSIN; URINARY BLADDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
L. Vinterjensen et al., "CONTRACTILE AND CYTOSKELETAL PROTEINS IN URINARY-BLADDER SMOOTH-MUSCLE FROM RATS TREATED WITH EPIDERMAL GROWTH-FACTOR", Urological research, 24(4), 1996, pp. 229-234

Abstract

Systemic treatment with epidermal growth factor (EGF) induces growth of all wall layers in the urinary tract of pigs and rats. The present study was initiated to describe morphological and biochemical changes in the bladder smooth muscle front rats treated with EGF for 4 weeks, Eight-week-old female Wistar rats were treated with subcutaneous injections of vehicle (n = 16) or EGF (n = 8, 150 mu g/kg per day) for 4 weeks. After EGF treatment the bladders were increased in weight [74.4 +/- 0.4 vs 122.1 +/- 0.5 mg, P < 0.001 (mean +/- SEM)]. Sodium dedecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) analyses of sixbladders from each group revealed that the total amounts of actin, myosin and desmin were statistically significantly increased by 62%, 61%and 154%, respectively. The relative amounts of actin and myosin wereunchanged whereas the desmin to actin ratio was significantly increased - as previously described in rat bladder smooth muscle hypertrophy. Light and electron microscopy of two bladders from each group revealed increased wall thickness involving all wall layers. The smooth muscle fibres at a midventral bladder location seemed only slightly hypertrophic - some degree of hyperplasia was therefore suspected. In conclusion, EGF treatment for 4 weeks induced a net synthesis of contractile and cytoskeletal proteins in the urinary bladder smooth muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:25:51