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Titolo:
SUPPRESSION OF TUMOUROGENICITY AND OVEREXPRESSION OF CELL-ADHESION MOLECULES IN AK-5 CELLS TRANSFECTED WITH WILD-TYPE P53 GENE
Autore:
KHAR A; PARDHASARADHI BVV;
Indirizzi:
CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Journal of Biosciences
fascicolo: 4, volume: 21, anno: 1996,
pagine: 445 - 454
SICI:
0250-5991(1996)21:4<445:SOTAOO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HISTIOCYTOMA; TUMOR-ANTIGEN; SURFACE PROTEIN; TRANSFORMATION; MUTATIONS; FIBRONECTIN; MORPHOLOGY; GROWTH;
Keywords:
WT P53; FIBRONECTIN; HYALURONECTIN; TUMOUROGENICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A. Khar e B.V.V. Pardhasaradhi, "SUPPRESSION OF TUMOUROGENICITY AND OVEREXPRESSION OF CELL-ADHESION MOLECULES IN AK-5 CELLS TRANSFECTED WITH WILD-TYPE P53 GENE", Journal of Biosciences, 21(4), 1996, pp. 445-454

Abstract

We have previously shown overexpression of p53 and rearrangement of the p53 gene in AK-5 tumour. In order to study the role of p53 in AK-5 tumourogenicity, we introduced wild-type p53 in AK-5 cells. We have shown suppression of tumourogenicity in AK-5 cells after transfection with wt p53, In one of the transfected clones 3B4, there was complete loss of tumour forming ability, Clone 3B4 also shelved cellular aggregation which correlated well with the higher expression of cell adhesion molecules like fibronectin and hyaluronectin. These observations demonstrate tumour suppression in AK-5 after introduction of wt p53.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:35:24