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Titolo:
QUANTITATIVE TRAIT LOCI FOR ETHANOL SENSITIVITY IN THE LS X SS RECOMBINANT INBRED STRAINS INTERVAL MAPPING
Autore:
MARKEL PD; FULKER DW; BENNETT B; CORLEY RP; DEFRIES JC; ERWIN VG; JOHNSON TE;
Indirizzi:
MILLENNIUM PHARMACEUT INC,640 MEM DR CAMBRIDGE MA 02139 UNIV COLORADO,INST BEHAV GENET BOULDER CO 80309 UNIV COLORADO,DEPT PSYCHOL BOULDER CO 80309 UNIV COLORADO,HLTH SCI CTR,SCH PHARM DENVER CO 80262 DEPT VET AFFAIRS,ALCOHOL RES CTR DENVER CO 80220
Titolo Testata:
Behavior genetics
fascicolo: 4, volume: 26, anno: 1996,
pagine: 447 - 458
SICI:
0001-8244(1996)26:4<447:QTLFES>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-SLEEP MICE; LONG-SLEEP; INITIAL CHARACTERIZATION; INDUCED ANESTHESIA; GENETIC-ANALYSIS; ALCOHOL; MARKERS; LINKAGE;
Keywords:
GENE MAPPING; LS AND SS; PHARMACOGENETICS; QUANTITATIVE GENETICS; MICE; ALCOHOL ACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
P.D. Markel et al., "QUANTITATIVE TRAIT LOCI FOR ETHANOL SENSITIVITY IN THE LS X SS RECOMBINANT INBRED STRAINS INTERVAL MAPPING", Behavior genetics, 26(4), 1996, pp. 447-458

Abstract

We are mapping the genes (quantitative trait loci or QTLs) that are responsible for individual differences in ethanol sensitivity, measuredas the duration of loss of righting reflex (LORR) and blood ethanol concentrations upon recovery of the righting reflex (BEG). The Long-Sleep (LS) and Short-Sleep (SS) selected lines of mice manifest an 18-fold difference in LORR and serve as a rodent model for ethanol sensitivity. The LS x SS recombinant inbred (RI) series, developed from LS and SS lines, are an important resource for QTL mapping of ethanol-relatedresponses. The current report summarizes the initial QTL analysis of LORR and BEC in the LS x SS strains and compares the results of correlational analysis with an interval-mapping approach. The data provide strong evidence for QTLs that influence ethanol sensitivity on mouse chromosomes 1 and 2 and possible QTLs on chromosomes 1, 3, 4, 5, 6, 7, 12, 13, 16, and 18. These results are compared to those from an F-2 cross which confirms QTLs on chromosomes 1, 2, 4, and 18.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:15:33