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Titolo:
STRUCTURES AND CONTRIBUTION TO THE ANTIGENICITY OF OLIGOSACCHARIDES OF JAPANESE CEDAR (CRYPTOMERIA-JAPONICA) POLLEN ALLERGEN CRY-J-I - RELATIONSHIP BETWEEN THE STRUCTURES AND ANTIGENIC EPITOPES OF PLANT N-LINKED COMPLEX-TYPE GLYCANS
Autore:
OGAWA H; HIJIKATA A; AMANO M; KOJIMA K; FUKUSHIMA H; ISHIZUKA I; KURIHARA Y; MATSUMOTO I;
Indirizzi:
OCHANOMIZU UNIV,FAC SCI,DEPT CHEM TOKYO 112 JAPAN TEIKYO UNIV,SCH MED,DEPT BIOCHEM TOKYO 177 JAPAN YOKOHAMA NATL UNIV,FAC EDUC,DEPT CHEM YOKOHAMA KANAGAWA 240 JAPAN
Titolo Testata:
Glycoconjugate journal
fascicolo: 4, volume: 13, anno: 1996,
pagine: 555 - 566
SICI:
0282-0080(1996)13:4<555:SACTTA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TASTE-MODIFYING PROTEIN; ACER-PSEUDOPLATANUS L; CARBOHYDRATE MOIETY; GLYCOPROTEIN ALLERGEN; CROSS-REACTIVITY; MAJOR ALLERGEN; SYCAMORE CELLS; ANTISERUM; IGE; MIRACULIN;
Keywords:
CRY J I; POLLEN ALLERGEN; CARBOHYDRATE EPITOPE; N-LINKED OLIGOSACCHARIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Ogawa et al., "STRUCTURES AND CONTRIBUTION TO THE ANTIGENICITY OF OLIGOSACCHARIDES OF JAPANESE CEDAR (CRYPTOMERIA-JAPONICA) POLLEN ALLERGEN CRY-J-I - RELATIONSHIP BETWEEN THE STRUCTURES AND ANTIGENIC EPITOPES OF PLANT N-LINKED COMPLEX-TYPE GLYCANS", Glycoconjugate journal, 13(4), 1996, pp. 555-566

Abstract

The oligosaccharide structures of Cry j I, a major allergenic glycoprotein of Cryptomeria japonica (Japanese cedar, sugi), were analysed by400 MHz H-1-NMR and two-dimensional sugar mapping analyses. The four major fractions comprised a series of biantennary complex type N-linked oligosaccharides that share a fucose/xylose-containing core and glucosamine branches including a novel structure with a nongalactosylated fucosylglucosamine branch. Rabbit polyclonal anti-Cry j I IgG antibodies cross-reacted with three different plant glycoproteins having the same or shorter N-linked oligosaccharides as Cry j I. ELISA and ELISA inhibition studies with intact glycoproteins, glycopeptides and peptides indicated that both anti-Cry j I IgGs and anti-Sophora japonica barklectin II (B-SJA-II) IgGs included oligosaccharide-specific antibodies with different specificities, and that the epitopic structures against anti-Cry j I IgGs include a branch containing alpha 1-6 linked fucose and a core containing fucose/xylose, while those against anti-B-SJA-II IgGs include nonreducing terminal mannose residues. The crossreactivities of human allergic sera to miraculin and Clerodendron Trichotomum lectin (CTA) were low and inhibition studies suggested that the oligosaccharides on Cry j I contribute little or only conformationally tothe reactivity of specific IgE antibodies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:56:47