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Titolo:
EFFECTIVENESS OF PEPPERMINT OIL AND PARAC ETAMOL IN THE TREATMENT OF TENSION HEADACHE
Autore:
GOBEL H; FRESENIUS J; HEINZE A; DWORSCHAK M; SOYKA D;
Indirizzi:
NIEMANNSWEG 147 D-24105 KIEL GERMANY CHRISTIAN ALBRECHTS UNIV KIEL,NEUROL KLIN D-2300 KIEL GERMANY
Titolo Testata:
Nervenarzt
fascicolo: 8, volume: 67, anno: 1996,
pagine: 672 - 681
SICI:
0028-2804(1996)67:8<672:EOPOAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
GER
Soggetto:
TEMPORALIS MUSCLE-ACTIVITY; EXTEROCEPTIVE SUPPRESSION; MENTHOL;
Keywords:
TENSION TYPE HEADACHE; PEPPERMINT OIL; HEADACHE THERAPY; MODE OF ACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
H. Gobel et al., "EFFECTIVENESS OF PEPPERMINT OIL AND PARAC ETAMOL IN THE TREATMENT OF TENSION HEADACHE", Nervenarzt, 67(8), 1996, pp. 672-681

Abstract

The effect of a locally applied peppermint oil preparation on tension-type headache was examined in the design of a randomized, placebo-controlled double-blind crossover study for the first time. The preparation was tested against both the reference substance acetaminophen and to the corresponding placebo. The liquid test preparation contained 10 g of peppermint oil and ethanol (90%) ad 100 (test preparation LI 170,Lichtwer Pharma, Berlin); the placebo was a 90% ethanol solution to which traces of peppermint oil were added for blinding purposes. The reference preparation contained 500 mg acetaminophen; the placebo tabletwas identical to the verum in size and appearance. The study includedthe analysis of 164 headache attacks of 41 patients of both sexes ranging between 18 and 65 years of age, suffering from tension-type headache in accordance with the IHS classification. Four headache episodes per patient were treated in a double-blind, randomized crossover design. Each headache attack was treated by the application of 2 capsules of the oral medication (1000 mg of acetaminophen or placebo) and the cutaneous application of the oil preparation (peppermint oil or placebo solution). The oil was spread largely across forehead and temples which was repeated after 15 and 30 minutes. Using a headache diary, the headache parameters were assessed after 15, 30, 45 and 60 minutes. Compared to the application of placebo, a 10% peppermint oil in ethanol solution significantly reduced the clinical headache intensity already after 15 minutes (p <0.01). This significant clinical reduction of the pain intensity continued over the one hour observation period. Acetaminophen, too, proved to be efficient compared to placebo (p <0.01). There was no significant difference between the efficacy of 1000 mg of acetaminophen and 10% peppermint oil in ethanol solution. Simultaneous application of 1000 mg of acetaminophen and 10% peppermint oil in ethanol solution leads to an additive effect which remains below the significance threshold, however. The patients reported no adverse events. This controlled study showed for the first time that a 10% peppermint oilin ethanol solution efficiently alleviates tension-type headache. Peppermint oil thus proves to be a well-tolerated and cost-effective alternative to usual therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 19:54:33