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Titolo:
TACHYKININERGIC SYNAPTIC TRANSMISSION IN THE CELIAC GANGLION OF THE GUINEA-PIG
Autore:
ZHAO FY; SAITO K; YOSHIOKA K; GUO JZ; MURAKOSHI T; KONISHI S; OTSUKA M;
Indirizzi:
UNIV BRISTOL,SCH BIOL SCI,WOODLAND RD BRISTOL BS8 1UG AVON ENGLAND TOKYO MED & DENT UNIV,FAC MED,DEPT PHARMACOL,BUNKYO KU TOKYO 113 JAPAN TOKYO MED & DENT UNIV,FAC MED,DIV SCI LAB,BUNKYO KU TOKYO 113 JAPAN SANKYO CO LTD,BIOL RES LAB,SHINAGAWA KU TOKYO 140 JAPAN MITSUBISHI KASEI INST LIFE SCI MACHIDA TOKYO 194 JAPAN
Titolo Testata:
British Journal of Pharmacology
fascicolo: 8, volume: 118, anno: 1996,
pagine: 2059 - 2066
SICI:
0007-1188(1996)118:8<2059:TSTITC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR MESENTERIC GANGLION; PRIMARY AFFERENT NEURONS; SUBSTANCE-P; SYMPATHETIC-GANGLIA; CELIAC GANGLION; SENSORY NEURONS; SPINAL-CORD; ANTAGONISTS; RAT; NEUROKININ;
Keywords:
AFTER-HYPERPOLARIZATION; SLOW EPSPS; SUBSTANCE P; NEUROKININ A; TACHYKININ RECEPTOR; GR71251;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
F.Y. Zhao et al., "TACHYKININERGIC SYNAPTIC TRANSMISSION IN THE CELIAC GANGLION OF THE GUINEA-PIG", British Journal of Pharmacology, 118(8), 1996, pp. 2059-2066

Abstract

1 The responses of coeliac ganglion neurones of the guinea-pig to electrical stimulation of the mesenteric nerves and applications of tachykinin receptor agonists were investigated by use of intracellular recording techniques. 2 Ganglion neurones were classified into three groups based on firing patterns in response to a depolarizing current pulse: phasic (38% of the population), tonic (39%) and atypical (23%). In the majority of phasic neurones (91%) a long after-hyperpolarization (LAH) lasting 5-8 s followed action potentials induced by a train of depolarizing current pulses. In contrast, LAK was rarely observed in tonic neurones (5%). 3 In most of tonic neurones (90%) slow excitatory post-synaptic potentials (e.p.s.ps) lasting 3-10 min were evoked by repetitive electrical stimulation of the mesenteric nerves. Prolonged depolarizations were also evoked in most tonic neurones by applications of substance P (SP), neurokinin A (NKA) or senktide, a tachykinin NK3 receptor agonist. 4 In most of phasic neurones (73%), mesenteric nerve stimulation did not induce an obvious depolarization but induced a prolonged inhibition of LAH lasting 3-10 min. Bath-applied tachykinin receptor agonists similarly induced an inhibition of LAH without causing depolarization in most of the phasic neurones. 5 GR71251 (5 mu M), a tachykinin NK1 receptor antagonist, partially depressed the nerve-evoked slow e.p.s.ps in tonic neurones and the nerve-evoked LAH inhibition inphasic neurones. 6 Capsaicin (0.1-5 mu M) induced a prolonged depolarization in tonic neurones and an inhibition of LAH in phasic neurones.7 A mixture of peptidase inhibitors potentiated the depolarization and the LAH inhibition evoked by nerve stimulation, SP and NKA, but not those evoked by senktide. 8 It is concluded that tonic neurones respond to repetitive mesenteric nerve stimulation preferentially with slow e.p.s.ps and that phasic neurones respond preferentially with LAH inhibition. The present study further suggests that SP and NKA, released from axon collaterals of primary afferent neurones, produce slow e.p.s.ps in tonic neurones and the LAH inhibition in phasic neurones via NK1receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:36:22