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Titolo:
EXPRESSION OF EPIDERMAL AND TRANSFORMING GROWTH-FACTORS IN PANCREATIC-CANCER
Autore:
LAKSHMIKESARI A; RADHAKRISHNA R; BHANUMATHI A; RAVI D; SRINIVAS G; NAIR MK; PILLAI MR;
Indirizzi:
REG CANC CTR,DIV LAB MED TRIVANDRUM 695011 KERALA INDIA REG CANC CTR,DIV LAB MED TRIVANDRUM 695011 KERALA INDIA REG CANC CTR,DIV RADIAT ONCOL TRIVANDRUM 695011 KERALA INDIA MED COLL HOSP,DEPT PATHOL THANJAVUR TAMIL NADU INDIA
Titolo Testata:
Oncology Reports
fascicolo: 5, volume: 3, anno: 1996,
pagine: 963 - 966
SICI:
1021-335X(1996)3:5<963:EOEATG>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR RECEPTOR;
Keywords:
EGF; TGF; PANCREATIC CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
A. Lakshmikesari et al., "EXPRESSION OF EPIDERMAL AND TRANSFORMING GROWTH-FACTORS IN PANCREATIC-CANCER", Oncology Reports, 3(5), 1996, pp. 963-966

Abstract

Pancreatic cancer continues to be a major clinical problem and littleis known of the various cellular and molecular events associated withthis malignancy. Growth factors and their receptors have important functions in the process of tumor progression. We have examined by immunocytochemistry, the expression of epidermal growth factor (EGF), its receptor (EGFR) and the transforming growth factors alpha and beta (TGFalpha and beta) in various grades of pancreatic adenocarcinoma. Expression of the growth factors was compared to their distribution in apparently normal pancreas and chronic pancreatitis. EGF, TGF alpha and TGF beta was expressed in normal pancreatic tissue while the expression of EGFR was slight and restricted. In chronic pancreatitis, this expression of EGFR increased and was found to be moderate in intensity. Expression of EGF, TGF alpha and TGF beta was similar to that seen in normal pancreas. Moderate to intense expression of EGF and TGF alpha was evident in all grades of pancreatic cancer. Expression of EGFR was intense in all these lesions. However, the most significant finding was the absence of TGF beta in all pancreatic cancer lesions. These resultsmay have significant implications for pancreatic tumor progression. EGF and TGF alpha are growth promoters influencing the expression of EGFR. TGF beta, on the other hand exerts an anti-proliferative effect and favours differentiation. It therefore appears that the balance between EGF and TGF alpha on the one hand and TGF beta on the other may be critical in the process of tumor progression, especially if one considers chronic pancreatitis as a pre-malignant condition and the growth factor expression associated with it.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 07:56:01