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Titolo:
NUCLEOSOME DISRUPTION BY HUMAN SWI SNF IS MAINTAINED IN THE ABSENCE OF CONTINUED ATP HYDROLYSIS/
Autore:
IMBALZANO AN; SCHNITZLER GR; KINGSTON RE;
Indirizzi:
MASSACHUSETTS GEN HOSP,DEPT MOL BIOL,WELLMAN 10 BOSTON MA 02114 MASSACHUSETTS GEN HOSP,DEPT MOL BIOL BOSTON MA 02114 HARVARD UNIV,SCH MED,DEPT GENET BOSTON MA 02115
Titolo Testata:
The Journal of biological chemistry
fascicolo: 34, volume: 271, anno: 1996,
pagine: 20726 - 20733
SICI:
0021-9258(1996)271:34<20726:NDBHSS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR-BINDING; TUMOR VIRUS PROMOTER; RNA-POLYMERASE-II; HEAT-SHOCK FACTOR; SACCHAROMYCES-CEREVISIAE; GLUCOCORTICOID RECEPTOR; DNA-BINDING; POSITIONED NUCLEOSOMES; MULTISUBUNIT COMPLEX; FACILITATED BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
A.N. Imbalzano et al., "NUCLEOSOME DISRUPTION BY HUMAN SWI SNF IS MAINTAINED IN THE ABSENCE OF CONTINUED ATP HYDROLYSIS/", The Journal of biological chemistry, 271(34), 1996, pp. 20726-20733

Abstract

We have examined the requirement for ATP in human (h) SWI/SNF-mediated alteration of nucleosome structure and facilitation of transcriptionfactor binding to nucleosomal DNA. hSWI-SNF-mediated nucleosome alteration requires hydrolysis of ATP or dATP. The alteration is stable upon removal of ATP from the reaction or upon inhibition of activity by excess ATP gamma S, indicating that continued ATP hydrolysis is not required to maintain the altered nucleosome structure, This stable alteration is sufficient to facilitate binding of a transcriptional activator protein; concurrent ATP hydrolysis was not required to facilitate binding. These data suggest sequential steps that can occur in the process by which transcription factors gain access to nucleosomal DNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:52:19