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Titolo:
IDEBENONE IMPROVES CEREBRAL MITOCHONDRIAL OXIDATIVE-METABOLISM IN A PATIENT WITH MELAS
Autore:
IKEJIRI Y; MORI E; ISHII K; NISHIMOTO K; YASUDA M; SASAKI M;
Indirizzi:
HYOGO INST AGING BRAIN & COGNIT DISORDERS,DIV CLIN NEUROSCI,520 SAISHO KO HIMEJI HYOGO 670 JAPAN HYOGO INST AGING BRAIN & COGNIT DISORDERS,DIV NEUROIMAGING RES HIMEJIHYOGO 670 JAPAN HYOGO INST AGING BRAIN & COGNIT DISORDERS,DIV BASIC NEUROSCI HIMEJI HYOGO 670 JAPAN
Titolo Testata:
Neurology
fascicolo: 2, volume: 47, anno: 1996,
pagine: 583 - 585
SICI:
0028-3878(1996)47:2<583:IICMOI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LACTIC-ACIDOSIS; BRAIN MITOCHONDRIA; EPISODES MELAS; COENZYME-Q10; ENCEPHALOMYOPATHY; THERAPY; ENCEPHALOPATHY; TOMOGRAPHY; MYOPATHY; CV-2619;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ikejiri et al., "IDEBENONE IMPROVES CEREBRAL MITOCHONDRIAL OXIDATIVE-METABOLISM IN A PATIENT WITH MELAS", Neurology, 47(2), 1996, pp. 583-585

Abstract

We report a 36-year-old man with MELAS in whom a 5-month course of high-dose oral idebenone, a derivative of coenzyme Q(10), increased markedly cerebral metabolic ratio of oxygen and oxygen extraction fractionwithout increased cerebral blood flow with PET. The results indicate that idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:23:33