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Titolo:
TREATMENT OF SECONDARY PROGRESSIVE MULTIPLE-SCLEROSIS WITH THE IMMUNOMODULATOR LINOMIDE - A DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT-STUDY WITH MONTHLY MAGNETIC-RESONANCE-IMAGING EVALUATION
Autore:
KARUSSIS DM; MEINER Z; LEHMANN D; GOMORI JM; SCHWARZ A; LINDE A; ABRAMSKY O;
Indirizzi:
HADASSAH UNIV HOSP,DEPT NEUROL IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT NEUROL IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT RADIOL IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,HADASSAH MED SCH IL-91905 JERUSALEM ISRAEL PHARMACIA AB,DEPT CLIN RES LUND SWEDEN
Titolo Testata:
Neurology
fascicolo: 2, volume: 47, anno: 1996,
pagine: 341 - 346
SICI:
0028-3878(1996)47:2<341:TOSPMW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; T-CELL SUBSET; LS-2616; MICE; DISEASE; RESPONSES; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Karussis et al., "TREATMENT OF SECONDARY PROGRESSIVE MULTIPLE-SCLEROSIS WITH THE IMMUNOMODULATOR LINOMIDE - A DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT-STUDY WITH MONTHLY MAGNETIC-RESONANCE-IMAGING EVALUATION", Neurology, 47(2), 1996, pp. 341-346

Abstract

Linomide (quinoline-3-carboxamide) is a synthetic immunomodulator that increases the natural killer cell activity. We previously demonstrated that linomide effectively inhibited the clinical and histopathologic signs of acute and chronic relapsing experimental autoimmune encephalomyelitis. We report a double-blind, placebo-controlled study to evaluate tolerability and to obtain preliminary indications of the clinical efficacy of linomide on secondary progressive MS. Thirty patients suffering from clinically definite and laboratory-supported secondary progressive MS, with an expanded disability status scale (EDSS) of 3.0 to 7.0, were included in this study. Patients were treated daily with linomide (2.5 mg) or placebo orally and were followed up for side effects and changes in their neurologic status; monthly MRI scans were taken throughout the treatment period. Twenty-four patients completed at least 6 months of treatment. Mild to moderate side effects, including muscle pains, arthralgia, and edema, were present in 11 of the 15 patients receiving placebo and in 13 of the 15 patients treated with linomide. At 24 weeks, the mean shift in EDSS was +0.272 +/- 0.156 in the placebo group versus -0.166 +/- 0.167 in the linomide group (p = 0.0451). The percentage of patients with evidence of ''activity'' on their MRI (new, enlarging, or new gadolinium diethylenetriaminepentaacetic acid [Gd-DTPA]-enhancing lesions) throughout the treatment period was 75%in the placebo group and 33% in the linomide group (p = 0.0205). The mean total number of ew Gd-DTPA-enhancing lesions per MRI scan for thesame period was 0.42 +/- 0.143 in the placebo group and 0.19 +/- 0.114 in the linomide group (p = 0.0387). In this study, linomide proved to be safe and well tolerated in patients with secondary progressive MS. In addition, our results indicate that linomide tends to inhibit theprogression of the disease, especially preventing the appearance of new active lesions in the MRI scans. Based on these results, two multicenter phase III trials are currently under way in the United States and in Europe and Australia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:30:59