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Titolo:
THE GLOMERULAR-FILTRATION RATE DURING PREGNANCY - SALINE INFUSION ENHANCES THE GLOMERULAR-FILTRATION RATE IN THE PREGNANT RAT
Autore:
FAAS MM; SCHUILING GA; KLOK PA; VALKHOF N; BAKKER WW;
Indirizzi:
UNIV GRONINGEN,DEPT PATHOL,OOSTERSINGEL 63 NL-9713 EZ GRONINGEN NETHERLANDS UNIV GRONINGEN,DEPT OBSTET & GYNAECOL NL-9713 EZ GRONINGEN NETHERLANDS
Titolo Testata:
Kidney & blood pressure research
fascicolo: 2, volume: 19, anno: 1996,
pagine: 121 - 127
SICI:
1420-4096(1996)19:2<121:TGRDP->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE ENDOTOXIN; RENAL HEMODYNAMICS; HUMAN PREECLAMPSIA; KIDNEY-FUNCTION; ANIMAL-MODELS; PSEUDOPREGNANCY; WOMEN; GFR;
Keywords:
GLOMERULAR FILTRATION RATE, PREGNANCY; SALINE INFUSION; INULIN CLEARANCE; CR-51-EDTA CLEARANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Faas et al., "THE GLOMERULAR-FILTRATION RATE DURING PREGNANCY - SALINE INFUSION ENHANCES THE GLOMERULAR-FILTRATION RATE IN THE PREGNANT RAT", Kidney & blood pressure research, 19(2), 1996, pp. 121-127

Abstract

The glomerular filtration rate (GFR) of pregnant rats is generally believed to exceed non-pregnant values. This notion is primarily based upon standard inulin clearances. However, the inulin clearance requirescontinuous infusion of inulin usually dissolved in saline. Since saline infusion per se in pregnancy may influence the GFR, in the present study the effect of saline infusion upon the GFR in pregnant as compared with cyclic rats was investigated using various methods. The standard inulin clearance was compared using the standard Cr-51-EDTA method which does not require saline infusion. Clearance of inulin dissolved in glucose (5% in distilled water) instead of saline was also tested, while the Cr-51-EDTA method was employed using additional fluid infusion with either saline or 5% glucose in distilled water in an identicalmanner as compared with the inulin method. The GFR was also studied in conscious rats using Cr-51-EDTA clearance with and without fluid infusion. The distribution volume of Cr-51-EDTA was measured in nephrectomized rats (pregnant and cyclic) with and without saline or glucose infusions. The results show a significant increase of the GFR in pregnant rats as compared with cyclic rats only when saline was infused during the measurement; thus, GFR measurements without fluid infusion or replacement of saline by glucose during the measurements did not show a significant increase of GFR in pregnant rats. The volume of distribution per gram body weight of Cr-51-EDTA after saline infusion, but not after glucose infusion, was significantly increased as compared with the values obtained without additional infusion. It is concluded that the increase of the GFR seen in pregnant rats when either the Cr-51-EDTAmethod or the inulin method is accompanied by saline loading is rather due to infusion of saline in the pregnant animal and not a result ofthe pregnant condition per se.

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Documento generato il 04/12/20 alle ore 12:41:07